| Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms |
Feixiang Bao; Lingyan Zhou; Rui Zhou; Qiaoying Huang; Junguo Chen; Sheng Zeng; Yi Wu; Liang Yang; Shufang Qian; Mengfei Wang; Xueying He1; Shan Liang; Juntao Qi; Ge Xiang; Qi Long; Jingyi Guo; Zhongfu Ying; Yanshuang Zhou; Qiuge Zhao; Jiwei Zhang; Di Zhang; Wei Sun; Mi Gao; Hao Wu; Yifan Zhao; Jinfu Nie; Min Li; Quan Chen; Jiekai Chen; Xiao Zhang; Guangjin Pan; Hong Zhang; Mingtao Li; Mei Tian; Xingguo Liu |
2022 |
Science Advances |
| Design, synthesis, and biological evaluation of novel 2’-methyl-2’-fluoro-6-
methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents |
Guoqiang Yao#; Jianchen Yu#; Cai Lin; Yujia Zhu; Anna Duana; Mengfeng Li; Jie Yuan*;Jiancun Zhang* |
2022 |
European Journal of Medicinal Chemistry |
| Structure- Based Discovery and Optimization of Furo[3,2-c]pyridin-4(5H)-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors |
Junhua Li#, Cheng Zhang#, Hongrui Xu, Chao Wang, Ruibo Dong, Hui Shen, Xiaoxi Zhuang,
Xiaoshan Chen, Qiu Li, Jibu Lu, Maofeng Zhang, Xishan Wu, Kerry M. Loomes, Yulai Zhou, Yan Zhang,
Jinsong Liu, and Yong Xu* |
2022 |
Journal of Medicinal Chemistry |
| CTCF functions as an insulator for somatic genes and a chromatin accessibility and structural regulator for pluripotency genes during reprogramming. |
Song Y#, Liang Z#, Zhang J#, Hu G#, Wang J, Li Y, Guo R, Dong X, Babarinde IA, Ping W, Sheng Y, Li H, Chen Z, Gao M, Chen Y, Zhang MQ, Hutchins AP, Fu X* and Yao H* |
2022 |
Cell Reports |
| Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors |
Qi Zhang, Bingyan Wu, Qitong Weng, Fangxiao Hu, Yunqing Lin, Chengxiang Xia, Huan Peng,Yao Wang, Xiaofei Liu, Lijuan Liu, Jiapin Xiong, Yang Geng, Yalan Zhao, Mengyun Zhang, Juan Du and Jinyong Wang |
2022 |
Cellular & Molecular Immunology |
| Human induced-T-to-natural killer cells have potent anti-tumour activities |
Zhi wu Jiang, Le Qin, Yuou Tang, Rui Liao, Jingxuan Shi, Binghe Jia, Shanglin Li, Diwei Zheng, Yuanbin Cui, Qitiing Wu, Youguo Long, Yao Yao, Zhihui Wei, Qilan Hong, Yi Wu, Yuanbang Mai, Shixue Gou, Xiaoping Li, Robert Weinkove, Sam Norton, Wei Luo, Weineng Feng, Hongsheng Zhou, Qifa Liu, Jiekai Chen, Liangxue Lai, Xinwen Chen, Duanqing Pei, Tomas Graf, Xingguo Liu, Yangqiu Li, Pentao Liu, Zhenfeng Zhang, Peng Li |
2022 |
Biomarker Research |
| Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites |
Yang Liu,Jizeng Zhou,Ting Lan1, Xiaoqing Zhou,Yang Yang, Chuan Li, Quanjun Zhang, Min Chen,
Shu Wei, Shuwen Zheng, Lingyin Cheng, Yuling Zheng, Liangxue Lai and Qingjian Zou |
2022 |
Cell Discovery |
| Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection |
Yudi Zhang, Qihong Yan, Kun Luo, Ping He, Ruitian Hou, Xinwei Zhao, Qian Wang, Haisu Yi, Huan Liang, Yijun Deng, Fengyu Hu, Feng Li, Xinglong Liu, Ying Feng, Pingchao Li, Linbing Qu, Zhaoming Chen, Qiang Pan-Hammarstr？m, Liqiang Feng,Xuefeng Niu,Ling Chen |
2022 |
Journal of Virology |
| Discovery of the first examples of threonine tyrosine kinase PROTAC degraders |
Jibu Lu, Yongjun Huang, Jing Huang, Rui He, Minhao Huang, Xiaoyun Lu, Yong Xu, Fengtao Zhou, Zhang Zhang, Ke Ding. |
2022 |
Journal of Medicinal Chemistry |
| Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection |
Yudi Zhang, Qihong Yan, Kun Luo, Ping He, Ruitian Hou, Xinwei Zhao, Qian Wang, Haisu Yi, Huan Liang, Yijun Deng, Fengyu Hu, Feng Li, Xinglong Liu, Ying Feng, Pingchao Li, Linbing Qu, Zhaoming Chen, Qiang Pan-Hammarstr？m, Liqiang Feng,Xuefeng Niu,Ling Chen |
2022 |
Journal of Virology |
| Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer |
Xiang Q, Wang C, Wu T, Zhang C, Hu Q, Luo G, Hu J, Zhuang X, Zou L, Shen H, Wu X, Zhang Y, Kong X, Liu J, Xu Y |
2022 |
Journal of Medicinal Chemistry |
| Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cells via regulation of the p53-checkpoint pathway |
Tongjie Wang,Chengxiang Xia,Qitong Weng, Kaitao Wang,Yong Dong,Sha Hao,Fang Dong,Xiaofei Liu,Lijuan Liu,Yang Geng,Yuxian Guan,Juan Du,Tao Cheng,Hui Cheng and Jinyong Wang |
2022 |
Haematologica |
| Author Correction: Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation |
Qi Long, Yanshuang Zhou, Hao Wu, Shiwei Du, Mingli Hu, Juntao Qi, Wei Li, Jingyi Guo, Yi Wu, Liang Yang, Ge Xiang, Liang Wang, Shouhua Ye, Jiayuan Wen , Heng Mao, Junwei Wang, Hui Zhao, Wai-Yee Chan, Jinsong Liu, Yonglong Chen , Pilong Li, Xingguo Liu |
2021 Dec; |
NATURE STRUCTURAL & MOLECULAR BIOLOGY |
| Organocatalytic Asymmetric Arylation of p_x001e_Quinone Phosphonates: A Green Access to Biaryl Monophosphorus Ligands |
Guodong Sun, Zhuofei Deng, Zhonghua Luo, Zhongqing Wang,Jiancun Zhang |
2021 Oct; |
Organic Letters |
| Exacerbated AIDS progression by PD-1 blockade during therapeutic vaccination in chronically SIV-infected rhesus macaques after ART treatment interruption |
Chunxiu Wu, Yizi He, Jin Zhao, Kun Luo, Ziyu Wen, Yudi Zhang, Minchao Li, Yilan Cui , Zijian Liu, Congcong Wang, Zirong Han, Guangye Li, Fengling Feng, Pingchao Li, Ling Chen, Caijun Sun |
2021 Nov; |
Journal of Virology |
| HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6 |
Menghui Yin, Meidie Cheng, Chengli Liu, Keli Wu, Wei Xiong, Ji Fang, Yinxiong Li, Biliang Zhang |
2021 Oct; |
iScience |
| Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis |
Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi |
2021 Oct; |
iScience |
| MAP2K6 Remodels Chromatin and Facilitates Reprogramming by Activating Gatad2b-Phosphorylation Dependent Heterochromatin Loosening |
Guangsuo Xing, Zichao Liu, Luyuan Huang, Danyun Zhao, Tao Wang, Hao Yuan, Yi Wu, Linpeng Li, Qi Long, Yanshuang Zhou, Zhihong Hao, Yang Liu, Jianghuan Lu, Shiting Li, Jieying Zhu, Bo Wang, Junwei Wang, Jing Liu, Jiekai Chen, Duanqing Pei, Xingguo Liu, Keshi Chen |
2021 Nov; |
Cell Death & Differentiation |
| Integrative Multi-omics Landscape of Non-structural Protein 3 of Severe Acute Respiratory Syndrome Coronaviruses |
Ruona Shi , Zhenhuan Feng , Xiaofei Zhang |
2021 Nov; |
Genomics Proteomics & Bioinformatics |
| Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation |
Long Q, Zhou Y, Wu H, Du S, Hu M, Qi J, Li W, Guo J, Wu Y, Yang L, Xiang G, Wang L, Ye S, Wen J, Mao H, Wang J, Zhao H, Chan WY, Liu J, Chen Y, Li P, Liu X |
2021 Oct; |
NATURE STRUCTURAL & MOLECULAR BIOLOGY |
| Capture of the newly transcribed RNA interactome using click chemistry |
Wang D, Yin M, Qin B, Zhang B, Bao X, Esteban MA |
2021 Oct; |
Nature Protocols |
| Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing |
Wang X, Liang Y, Zhao J, Li Y, Gou S, Zheng M, Zhou J, Zhang Q, Mi J, Lai L |
2021 Oct; |
Cell Discovery |
| Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression |
Xu Y, Tao J, Yu X, Wu Y, Chen Y, You K, Zhang J, Getachew A, Pan T, Zhuang Y, Yuan F, Yang F, Lin X, Li YX |
2021 Oct; |
JCI Insight |
| Toll-like receptor 2 signaling in liver pathophysiology |
Getachew A, Hussain M, Huang X, Li Y |
2021 Nov; |
Life Sciences |
| SAGE1: a potential target antigen for lung cancer T-cell immunotherapy |
Li Y, Zhang Y, Yu X, Liu Q, Gong H, Chen AA, Zheng H, Zhong S |
2021 Aug; |
Molecular cancer therapeutics |
| Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity |
Zou Q, Qi H |
2021 Oct; |
International Journal of Biochemistry and Cell Biology |
| A recombinant selective drug-resistant M. bovis BCG enhances the bactericidal activity of a second-line anti-tuberculosis regimen |
Chiwala G, Liu Z, Mugweru JN, Wang B, Khan SA, Bate PNN, Yusuf B, Hameed HMA, Fang C, Tan Y, Guan P, Hu J, Tan S, Liu J, Zhong N, Zhang T |
2021 Aug; |
Biomedicine & Pharmacotherapy |
| Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine and Linezolid in a Murine Model of Tuberculosis |
Wei Yu, Yusuf Buhari, Shuai Wang, Xirong Tian, H M Adnan Hameed, Zhili Lu, Gift Chiwala, Md Shah Alam, Gregory M Cook, Dmitry A Maslov, Nanshan Zhong, Tianyu Zhang |
2021 Sep; |
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY |
| The mechanisms of action of Plasmodium infection against cancer |
Xiaoping Chen, Li Qin, Wen Hu, Dickson Adah |
2021 Jul; |
Cell Communication and Signaling |
| Recapitulative haematopoietic development of human pluripotent stem cells in the absence of exogenous haematopoietic cytokines |
Elena S Philonenko, Ying Tan, Cuihua Wang, Baoyun Zhang, Zahir Shah, Jianguang Zhang, Hanif Ullah, Sergei L Kiselev, Maria A Lagarkova, Dandan Li, Yong Dai,Igor M Samokhvalov |
2021 Aug; |
Journal of cellular and molecular medicine |
