| Treatment of liver failure utilizing multi-cell lineage liver microtissue |
Chen, Mengqi; Wang, Heming; Zhao, Yicheng; Tao, Huafeng; Sharma, Amar Deep; Yuan, Qinggong; Ott, Michael; Li, Wenjuan; Lai, Liangxue; Song, Guangqi; Dai, Zhen |
2026 |
JHEP Reports |
| VE-cadherin dual reporter mouse lines for studying endothelial functions |
Zhang, Lu; Chen, Jun; Peng, Hao; Lu, Xiaoyu; Wu, Xue; Ma, Wanli; Ren, Wei; Yin, Xiaoning; Wu, Bingruo; Zhang, Jingran; Dougherty, Carson; Xie, Jingke; Zhou, Bin; Cai, Chen-Leng |
2026 |
Circulation Research |
| Structure-guided design of 7-azaindole DNMT1 inhibitors active against hypomethylating agent–resistant acute myeloid leukemia |
Tang, Shibing; Zong, Liangyi; Ma, Shuyuan; Shang, Yini; Wei, Jiale; Liu, Jianguang; Cui, Ying; Guo, Huahui; Zou, Kang; Wang, Kezhi; Li, Hongkun; Ye, Fei; Huang, Jing; Luo, Cheng; Li, Zhihai; Baylin, Stephen B.; Kong, Xiangqian |
2026 |
Proceedings of the National Academy of Sciences |
| Structure-based virtual screening of new Skp1 inhibitor chemotypes targeting F-box binding interface |
Hussain, Muzammal; Lu, Yongzhi; Wang, Gui-Zhen; Tariq, Muqddas; Zhang, Jiancun; Zhou, Guang-Biao; Liu, Jinsong |
2026 |
Drug Design, Development and Therapy |
| MAP2K6 directly phosphorylates BCL2L13 to mediate mitophagy for suppressing tumorigenicity |
Xing, Guangsuo; Huang, Yile; Liu, Xiwen; Li, Linpeng; Liu, Zichao; Wu, Yi; Zhou, Yanshuang; Ding, Yingzhe; Chen, Baodan; Xue, Guanru; Li, Zijing; Hao, Zhihong; Liu, Yang; Fan, Wenhui; Ding, Haolin; Liang, Shan; He, Jingcai; Wang, Junwei; Zhang, Jian; Qin, Dajiang; Wang, Wuming; Lu, Gang; Chan, Wai-Yee; Ran, Pixin; Ju, Huaiqiang; Dong, Ming; Liang, Wenhua; Liu, Xingguo; Chen, Keshi |
2026 |
Cell Reports |
| Spontaneous whole genome duplication renders mouse embryonic fibroblasts resistant to reprogramming |
Li, Wei; Zhong, Lingyu; Li, Pengli; Zhai, Ziwei; Lin, Runxia; Ke, Minjing; Fan, Yixin; Liu, Yu; Fu, Yu; Qin, Yue; Zhao, Chengchen; Wang, Bo; Kuang, Junqi; Pei, Duanqing |
2026 |
Cell & Bioscience |
| The naked mole-rat cGAS promotes homologous recombination repair and delays aging |
Du, Chenxi; Xie, Yuying; Ding, Haolin; E, Taoxia; Li, Linpeng; Liu, Xingguo |
2026 |
Science Bulletin |
| Dose-resolved control of somatic reprogramming by rora |
Wang, Haiyun; Li, Yusha; Yin, Chunkou; Zhang, Zhen; Wang, Yixuan; Li, Yi; Li, Chuang; Lin, Runxia; Zhang, Xiaoli; Guo, Jing; Luo, Rongping; Li, Shumin; Zhang, Lv; Zhuang, Yingting; Xu, Anchun; Wan, Jiani; Xiao, Lizhan; Chen, Bailing; Yu, Shengyong; Kumar, Manish; Liu, Jing |
2026 |
Stem Cell Reports |
| Non-gene-edited neural stem cells reverse neuroinflammation and microbiota dysbiosis in a sprague-dawley rat model of autism spectrum disorder |
Liu, Zhaoming; Wu, Caixia; Li, Xianjie; Wang, Han; Majid, Muhammad; Basnet, Rajesh; Li, Zhiyuan |
2026 |
Translational psychiatry |
| Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and parkinson’s disease models |
Du, Shiwei; Long, Qi; Zhou, Yanshuang; Fu, Jiangqin; Wu, Hao; Yang, Liang; Xie, Yaohang; Ding, Yingzhe; Zhang, Maolei; Guo, Jingyi; Wang, Mengfei; Lin, Jiajun; Hu, Mingli; Zhang, Jian; Yao, Deyang; Li, Wei; Bao, Feixiang; Xiang, Ge; Wu, Yi; Huang, Yile; Liang, Haozhao; Wang, Rui; Li, Heying; Chen, Baodan; Li, Chong; Wang, Junwei; Zhang, Jiwei; Qin, Dajiang; Sun, Jianwei; Zhu, Yun; Sun, Fei; Wang, Wuming; Lu, Gang; Chan, Wai-Yee; Zhao, Hui; Liu, Chenli; Liu, Xingguo |
2026 |
Cell |
| iceDP: Identifying inter-chromatin engagement via density peaks clustering algorithm |
Chen, Ruhai; Chen, Jiekai; Shi, Lingling; He, Jiangping |
2026 |
Briefings in Bioinformatics |
| Coiled-coil heterodimer-mediated split base editing systems enable flexible and robust nucleotide substitutions |
Mu, Shuangshuang; Li, Qianru; Chen, Menglong; Li, Ziqi; Ma, Yuke; Li, Yuqi; Song, Yiran; Hou, Shuangying; Ding, Yuting; Ju, Jialu; Lin, Yue; Zhang, Jian; Yang, Yuanxi; Ren, Xue; Li, Nan; Jin, Qin; Lai, Liangxue; Wang, Kepin; Shi, Hui |
2026 |
Nature Communications |
| Post-transcriptional control of endogenous retroviruses by L1td1 suppresses totipotency acquisition in pluripotent stem cells |
Wu, Yi; Liu, Yang; Huang, Yile; Hao, Zhihong; Li, Wenxin; Li, Yukun; Zhang, Maolei; Li, Linpeng; Qin, Dajiang; Chen, Keshi; Liu, Xingguo |
2026 |
Cell Discovery |
| Hyperactivation of mTORC1 blocks stem cell fate transitions through TFE3-NuRD association |
Li, Peizhi; Xu, Shuhui; Wu, Xinyu; Gao, Yin; Ahmed, Tanveer; Huang, Yinghua; Qin, Dajiang; Qin, Baoming; Wang, Lulu; Xu, Xueting |
2026 |
EMBO Reports |
| Cytoplasm-nucleus shuttling of TET2: An intrinsic brake in colorectal cancer progression |
Li, Changpeng; Meng, Fei; He, Jingcai; Dong, Linna; He, Yuexian; Guo, Qing; Zeng, Kerou; Wu, Yanhua; Ge, Haofei; Chen, Shiyu; Yang, Tingting; Zhou, Yusheng; Wang, Yulu; Liu, Lin; Ren, Qiwen; He, Meiai; Sun, Hao; Liang, Lining; Guo, Lin; Li, Xiaolin; Hong, Jiahong; Huang, Zhenhua; Zheng, Hui |
2026 |
Cell Death & Disease |
| Heterogenous calcium response in arterial and venous endothelial cells |
Wang, Yu‐xiang; Chen, Qi |
2026 |
Acta Physiologica |
| Structural basis for BCL7B-mediated ncBAF-nucleosome engagement |
Sun, Fahui; Zou, Binqian; Li, He; Xu, Chongshen; Luo, Qiaohong; Wang, Chi; Xu, Pengqi; Pei, Duanqing; Chen, Jiekai; Qin, Dajiang; Zhang, Ying; He, Jun |
2026 |
Nucleic Acids Research |
| A single-cell time-series atlas of endothelial cell embryonic development |
Lin, Lihui; Zhong, Jing; Jiang, Fuqing; Wang, Yu-xiang; Ma, Lan-yue; Yang, Jia-xin; Li, Yu-yan; Gao, Rong-Rong; Feng, Huijian; Cai, Baomei; Feng, Ziyu; Zhou, Xin; Shu, Ya-hai; Chen, Pan; Wu, Xue; Cai, Chen-Leng; Wang, Qiang; Wu, Guangming; Pei, Duanqing; Cao, Shangtao; Liu, Yang; Peng, Guangdun; Chen, Jiekai; Chen, Qi |
2026 |
Cell |
| Discovery of XYD270 as a potent, selective, and orally efficacious BRD9 PROTAC for cancer therapy |
Huang, Yumin; Cheng, Guizhen; Tang, Xin; Chen, Zhiming; Zhang, Cheng; Hu, Jiankang; Chen, Xiaoshan; Wang, Jun; Chen, Zhaoming; Zhao, Mohan; Liu, Jinsong; Xu, Tingting; Ma, Jinming; Zhang, Yan; Lin, Bin; Shen, Hui; Xu, Yong |
2026 |
Journal of Medicinal Chemistry |
| Repurposing Cas13’s collateral cleavage activity to mitigate host cell dominance in interspecies chimera formation |
Wang, Jiaowei; Lai, Liangxue |
2026 |
Developmental Cell |
| Discovery and optimization of 4-aminopteridin-7(8H)-one derivatives as potent and selective mTOR inhibitors with favorable pharmacodynamic and safety characteristics |
Wang, Danyang; Li, Gengwu; Liu, Jianguang; Li, Mengxin; Peng, Xudan; Deng, Jinfeng; Zhao, Shujie; Zou, Kang; Zhang, Xiaohan; Liu, Dan; Tortorella, Micky D.; Wu, Linping; Tang, Shibing |
2026 |
Journal of Medicinal Chemistry |
| A cocktail hydrogel promoting the functional interneurons regeneration of human neural progenitor cells for brain injury therapy |
Zhang, Di; Chen, Jun; Lin, Huaisong; Zhou, Min; Hou, Jinfei; Sun, Wei; Xing, Qi; Huang, Wenhao; Zhang, Yanqi; Guo, Yiping; Liu, Chunhua; Lin, Aiping; Zhang, Cong; Huang, Yuhua; Tao, Li-En; Xie, Bowen; Zhang, Jian; Chen, Qianyu; Shan, Yongli; Zhu, Yanling; Pan, Guangjin; Wu, Lin-Ping |
2026 |
Journal of Advanced Research |
| Key imidazolyl groups that induce phenylalanine flipping enhance the efficacy of oral BRD9 inhibitors for AML treatment |
Chen Z.; Zhang C.; Shen H.; Xu H.; Huang Y.; Dong R.; Tang X.; Chai S.; Li J.; Xu J.; Zhang X.; Zhang Y.; Wu X.; Xu Y. |
2025 |
Acta pharmaceutica Sinica B |
| Dissecting the functional roles of CTCF and CTCF-s in human embryonic stem cells |
Hongxin Zhong, Yuli Lu, Jie Zhang, Gongcheng Hu, Guangjin Pan, Hongjie Yao |
2025 |
Journal of genetics and genomics |
| Cryo-EM structure of TMEM164 reveals distinct phospholipid remodeling mechanisms with anti-ferroptotic potential |
Minjing Ke, Yuanyue Shan, Ziwei Zhai, Guoqiang Yao, Xinyi Guo, Xiaoxi Li, Zichao Wu, Huifeng Chen, Mengmeng Zhang, Meiyu Chen, Ying Li, Chengchen Zhao, Bo Wang, Micky D Tortorella, Xiaodong Shu, Mingfeng Zhang, Junqi Kuang, Duanqing Pei |
2025 |
NATURE COMMUNICATIONS |
| METTL3 and METTL14 determine human neural fate specifications |
Zhang Y.; Zhang J.; Lin H.; Wang J.; Chen Q.; Zhou T.; Xing Q.; Pan G.; Shan Y. |
2025 |
Nucleic Acids Research |
| Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts |
Deng M.; He D.; Wang X.; Yuan Y.; Wang L.; Hou Y.; Zhu Q.; Zhou C.; Mai Z.; Zhang Y.; Nie Z.; Song Y.; Wu Q.; Pan L.; Dong B.; Xiong Z.; Li D.; Liu D.; Xu J.; Qin D.; Zheng H.; Zhao Y.; Tang P.; Wang J.; Print C.; Jauch R.; Zhang W.; Wu G.; Bao X. |
2025 |
NATURE COMMUNICATIONS |
| Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development |
Zhihong Hao, Yi Wu, Yile Huang, Maolei Zhang, Yang Liu, Yueqiao Li, Wenxin Li, Zifeng Ruan, Jian Zhang, Yingzhe Ding, Linpeng Li, Guangsuo Xing, Zichao Liu, Yanshuang Zhou, Qi Wang, Keshi Chen, Wuming Wang, Gang Lu, Dajiang Qin, Wai-Yee Chan, Xingguo Liu |
2025 |
NATURE COMMUNICATIONS |
| Breaking the link between morphology and potency for mESCs |
Yixin Fan, Xiaomin Wang, Ziwei Zhai, Tao Huang, Wei Li, Zechuan Liang, Zhaoyi Ma, Yu Fu, Pengli Li, Junqi Kuang, Duanqing Pei |
2025 |
Cell and Bioscience |
| Polyomino reconstructs spatial transcriptomic profiles with single-cell resolution via a region-allocation method |
Quanyou Cai, Lihui Lin, Xin Liu, Jiekai Chen |
2025 |
Genome Research |
