| STING directly interacts with PAR to promote apoptosis upon acute ionizing radiation-mediated DNA damage |
Yirong Sun, Saba R Aliyari, Kislay Parvatiyar, Lulan Wan, Anjie Zhen, Wei Sun, Xiaobo Han, Adele Zhang, Ethan Kato, Helen Shi, Elena De Schutter, William H McBride, Samuel W French, Genhong Cheng
|
2025 |
Cell Death and Differentiation |
| Learning Phenotype Associated Signature in Spatial Transcriptomics with PASSAGE |
Chen-Kai Guo, Chen-Rui Xia, Guangdun Peng, Zhi-Jie Cao, Ge Gao |
2025 |
Small Methods |
| An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape |
Weiqi Deng, Xuefeng Niu , Ping He, Qihong Yan, Huan Liang, Yongping Wang, Lishan Ning, Zihan Lin, Yudi Zhang, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen
|
2025 |
Frontiers in immunology |
| Capture primed pluripotency in guinea pig |
Jing Guo, Runxia Lin, Jinpeng Liu, Rongrong Liu, Shuyan Chen, Zhen Zhang, Yongzheng Yang, Haiyun Wang, Luqin Wang, Shengyong Yu, Chunhua Zhou, Lizhan Xiao, Rongping Luo, Jinjin Yu , Lihua Zeng, Xiaoli Zhang, Yusha Li, Haokaifeng Wu, Tao Wang , Yi Li, Manish Kumar, Ping Zhu, Jing Liu
|
2025 |
Stem Cell Reports |
| Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy |
Wenjing Bai, Jinxin Xu, Wenbin Gu, Danyang Wang, Ying Cui, Weidong Rong, Xiaoan Du, Xiaoxia Li, Cuicui Xia, Qingqing Gan, Guantao He, Huahui Guo, Jinfeng Deng, Yuqiong Wu, Ray-Whay Chiu Yen, Srinivasan Yegnasubramanian, Scott B Rothbart, Cheng Luo, Linping Wu, Jinsong Liu, Stephen B Baylin, Xiangqian Kong |
2025 |
Nature Communications |
| Discovery of a Potent and Selective GSPT1 Molecular Glue Degrader for the Treatment of Castration-Resistant Prostate Cancer |
Hui Shen, Hongrui Xu, Weiqin Jin, Tianbang Wu, Jiankang Hu, Cheng Zhang, Zhixin Zhong, Junhua Li, Rui Mao, Sheng Zhang, Xiao Zhang, Xishan Wu, Jeff B Smaill, Jinxin Xu, Yan Zhang, Yong Xu |
2025 |
Journal of medicinal chemistry |
| Dual-nuclease single-cell lineage tracing by Cas9 and Cas12a |
Cheng Chen, Yuanxin Liao, Miao Zhu, Li Wang, Xinran Yu, Meishi Li, Guangdun Peng |
2025 |
Cell reports |
| Leveraging spatial multiomics to unravel tissue architecture in embryo development |
Fuqing Jiang, Haoxian Wang, Zhuxia Li, Guizhong Cui, Guangdun Peng |
2025 |
Trends in genetics |
| MSC-mediated mitochondrial transfer restores mitochondrial DNA and function in neural progenitor cells of Leber's hereditary optic neuropathy |
Rui Wang, Feixiang Bao, Manjiao Lu, Xiaoyun Jia, Jiahui Xiao, Yi Wu, Qingjiong Zhang, Xingguo Liu |
2024 |
Science China-Life Sciences |
| Reconstitution of pluripotency from mouse fibroblast through Sall4 overexpression |
Lizhan Xiao,Zifen Huang,Zixuan Wu,Yongzheng Yang,Zhen Zhang,Manish Kumar,Haokaifeng Wu,Huiping Mao,Lihui Lin,Runxia Lin,Jingxian Long,Lihua Zeng,Jing Guo,Rongping Luo,Yi Li,Ping Zhu,Baojian Liao,Luqin Wang,Jing Liu |
2024 |
Nature Communications |
| KMT2D deficiency leads to cellular developmental disorders and enhancer dysregulation in neural-crest-containing brain organoids |
Ziyun Shan, Yingying Zhao, Xiuyu Chen, Guodong Zhan, Junju Huang, Xuejie Yang,Chongshen Xu,Ning Guo,Zhi Xiong,Fang Wu,Yujian Liu,He Liu,Biyuan Chen,Bingqiu Chen,Jiaoyang Sun,Jiangping He,Yiping Guo , Shangtao Cao, Kaixin Wu, Rui Mao, Guangming Wu, Lihui Lin, Xiaobing Zou, Jie Wang, Jiekai Chen |
2024 |
Science Bulletin |
| A single-dose circular RNA vaccine preventsZika virus infection without enhancing dengue severity in mice |
Xinglong Liu,Zhengfeng Li,Xiaoxia Li,Weixuan Wu,Huadong Jiang,Yufen Zheng,Junjie Zhou,Xianmiao Ye,Junnan Lu,Wei Wang,Lei Yu,Yiping Li,Linbing Qu,Jianhua Wang,Feng Li,Ling Chen,Linping Wu, Liqiang Fen |
2024 |
Nature Communication |
| METTL3/METTL14 maintain human nucleoli integrity by mediating SUV39H1/H2 degradation |
Yongli Shan,Yanqi Zhang,Yanxing Wei,Cong Zhang,Huaisong Lin,Jiangping He,Junwei Wang,Wenjing Guo,Heying Li,Qianyu Chen,Tiancheng Zhou,Qi Xing,Yancai Liu,Jiekai Chen,Guangjin Pan |
2024 |
Nature Communications |
| Hydrophobic core evolution of major histocompatibility complex class I chain-related protein a for dramatic enhancing binding affinity |
Wenxuan Cai,Siqi Peng,Ye Tian,Yifeng Bao,Qiang Liu,Yan Dong,Zhaoduan Liang,Qi Liu, Yuefei Ren,Peng Ding,Jinsong Liu,Tingting Xu,Yi Li |
2024 |
International Journal of Biological Macromolecules |
| YIPF2 regulates genome integrity |
Xiao Zhang,Tao Wang |
2024 |
Cell and Bioscience |
| Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging |
Yudong Fu,Fan Jiang,Xiao Zhang,Yingyi Pan,Rui Xu,Xiu Liang,Xiaofen Wu,Xingqiang Li,Kaixuan Lin,Ruona Shi,Xiaofei Zhang,Dominique Ferrandon,Jing Liu,Duanqing Pei,Jie Wang,Tao Wang |
2024 |
Nature Communications |
| In vivo evaluation of guide-free Cas9-induced safety risks in a pig model |
Weikai Ge,Shixue Gou,Xiaozhu Zhao,Qin Jin,henpeng Zhuang,Yu Zhao,Yanhui Liang,Zhen Ouyang,Xiaoyi Liu,Fangbing Chen,Hui Shi,Haizhao Yan,Han Wu,Liangxue Lai,Kepin Wang |
2024 |
Signal Transduction and Targeted Therapy |
| NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations |
Liang Yang,Zifeng Ruan,Xiaobing Lin,Hao Wang,Yanmin Xin,Haite Tang,Zhijuan Hu,Yunhao Zhou,Yi Wu,Junwei Wang,Dajiang Qin,Gang Lu,Kerry M Loomes,Wai-Yee Chan,Xingguo Liu |
2024 |
Nature Communications |
| Microbiome-induced reprogramming in post-transcriptional landscape using Nanopore direct RNA sequencing |
Zihe Xu,Xiaoqi Zheng,Jiajun Fan,Yuting Jiao,Sihao Huang,Yingyuan Xie,Shunlan Xu,Yi Lu,Anrui Liu,Runzhou Liu,Ying Yang,Guan-Zheng Luo,Tao Pan,Xiaoyun Wang |
2024 |
Cell Reports |
| Comparison of seven CD19 CAR designs in engineering NK cells for enhancing anti-tumour activity |
Yao Wang,Jianhuan Li,Zhiqian Wang,Yanhong Liu,Tongjie Wang,Mengyun Zhang,Chengxiang Xia,Fan Zhang,Dehao Huang,Leqiang Zhang,Yaoqin Zhao,Lijuan Liu,Yanping Zhu,Hanmeng Qi,Xiaofan Zhu,Wenbin Qian,Fangxiao Hu,Jinyong Wang |
2024 |
Cell Proliferation |
| Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer |
Xi-Shan Wu,Xiao-Yu Luo,Cheng-Chang Li,Xiao-Fan Zhao,Cheng Zhang,Xiao-Shan Chen,Zhi-Fang Lu,Tong Wu,Hao-Nan Yu,Chao Peng,Qing-Qing Hu,Hui Shen,Yong Xu,Yan Zhang |
2024 |
Acta Pharmacologica Sinica |
| Variant PRC1 subunit RYBP/YAF2 forms condensate with RING1B and promotes H2AK119ub deposition |
Yanjiang Liu,Gongcheng Hu,Shengxiong Yang,Chenghong Yan,Juehan Wang,Guangjin Pan,Hongjie Yao |
2024 |
Science China-Life Sciences |
| Selecting Monoclonal Cell Lineages from Somatic Reprogramming Using Robotic-Based Spatial-Restricting Structured Flow |
Xueping Chen,Ke Fan,Jun Lu,Sheng Zhang,Jianhua Dong,Jisheng Qin,Weihua Fan,Yan Wang,Yiyuan Zhang,Huo Peng,Zhizhong Zhang,Zhiyong Sun,Chunlai Yu,Yucui Xiong,Yan Song,Qingqing Ye,Shiwen Mai,Yuanhua Wang,Qizheng Wang,Fengxiang Zhang,Xiaohui Wen, Tiancheng Zhou,Li Han,Mian Long,Guangjin Pan,Julian F Burke,Xiao Zhang |
2024 |
Research |
| Discovery of highly potent and efficient CBP/p300 degraders with strong in vivo antitumor activity |
Jiankang Hu,Hongrui Xu,Tianbang Wu,Cheng Zhang,Hui Shen,Ruibo Dong,Qingqing Hu,Qiuping Xiang,Shuang Chai,Guolong Luo,Xiaoshan Chen,Yumin Huang,Xiaofan Zhao,Chao Peng,Xishan Wu,Bin Lin,Yan Zhang,Yong Xu |
2024 |
Journal of Medicinal Chemistry |
| Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury |
Jian-Bo Cao,Shu-Tong Zhu,Xiao-Shan Huang,Xing-Yuan Wang,Meng-Li Wu,Xin-Li,Feng-Liang Liu,Ling Chen,Yong-Tang Zheng,Jian-Hua Wang |
2024 |
Virologica Sinica |
| CTCF mutation at R567 causes developmental disorders via 3D genome rearrangement and abnormal neurodevelopment |
Jie Zhang,Gongcheng Hu,Yuli Lu,Huawei Ren,Yin Huang,Yulin Wen,Binrui Ji,Diyang Wang, Haidong Wang,Huisheng Liu,Ning Ma, Lingling Zhang,Guangjin Pan,Yibo Qu,Hua Wang,Wei Zhang,Zhichao Miao, Hongjie Yao |
2024 |
Nature Communications |
| Autophagy is essential for human myelopoiesis |
Jiaming Gu,Yanling Zhu,Huaisong Lin,Yuhua Huang,Yanqi Zhang,Qi Xing,Baoqiang Kang,Zhishuai Zhang,Mingquan Wang,Tiancheng Zhou,Yuchan Mai,Qianyu Chen,Fei Li,Xing Hu,Shuoting Wang,Jiaojiao Peng, Xinrui Guo,Bing Long,Junwei Wang,Minghui Gao,Yongli Shan,Yazhou Cui,Guangjin Pan |
2024 |
Stem Cell Reports |
| HBO1 determines SMAD action in pluripotency and mesendoderm specification |
Cong Zhang,Yongli Shan,Huaisong Lin,Yanqi Zhang,Qi Xing,Jinmin Zhu,Tiancheng Zhou, Aiping Lin,Qianyu Chen,Junwei Wang,Guangjin Pan |
2024 |
Nucleic Acids Research |
| Redox-modulated SNX25 as a novel regulator of GPCR-G protein signaling from endosomes |
Yulong Zhang,Zhijun Yu,Mingwei Sun,Ruyue Du,Hanhan Gao,Qiankun Dai,Yan Dong,Cuicui Liu,Menghui Yin,Tingting Xu,Xiaofei Zhang,Jinsong Liu,Jinxin Xu |
2024 |
Redox Biology |
| NY-ESO-1-specific T cell receptor-engineered T cells and Tranilast, a TRPV2 antagonist bivalent treatment enhances the killing of esophageal cancer: a dual-targeted cancer therapeutic route |
Obed Boadi Amissah,Wenfang Chen,Jean de Dieu Habimana,Yirong Sun,Lihui Lin,Yujie Liu,Ling Wang,Zhaoming Liu,Omar Mukama,Rajesh Basnet,Hohua Liu,Junyi Li,Xuanyan Ding,Lingshuang Lv,Min Chen,Yalin Liang,Rongqi Huang,Zhiyuan Li |
2024 |
Cancer Cell International |
