一、教育经历

2014年09月-2020年01月 中国科学院广州生物医药与健康研究院，细胞生物学，博士

二、工作经历

2025年1月-至今 中国科学院广州生物医药与健康研究院，发育与再生医学研究所，研究员

2022 年 12 月-2024 年 12 月 中国科学院广州生物医药与健康研究院，华南干细胞与再生医学研究所，副研究员

2022 年 4月-2022年11月 中国科学院广州生物医药与健康研究院，华南干细胞与再生医学研究所，助理研究员

2020年4月-2022年3月 中国科学院广州生物医药与健康研究院，博士后

1.     广州市黄埔区广州开发区精英人才, 2022年

2.     外国青年人才计划, 2022年

3.     中国科学院国际人才计划（CAS-PIFI）-特需人才，2021年

4.     广州生物医药与健康研究院优秀学生奖, 2019年

5.     中国科学院与发展中国家科学院院长奖学金（CAS-TWAS）, 2014年

    主要学术成果

1.      Md. Abdul Mazid^#*, Carl Ward^#, Zhiwei Luo^#, Chuanyu Liu^#, Yunpan Li, Yiwei Lai, Liang Wu, Jinxiu Li, Wenqi Jia, Yu Jiang, Hao Liu, Lixin Fu, Yueli Yang, David P. Ibañez, Junjian Lai, Xiaoyu Wei, Juan An, Pengcheng Guo, Yue Yuan, Qiuting Deng, Yang Wang, Ying Liu, Fei Gao, Junwen Wang, Shahriar Zaman, Baoming Qin, Guangming Wu, Patrick H. Maxwell, Xun Xu, Longqi Liu*, Wenjuan Li*, Miguel A. Esteban* (2022). Rolling back of human pluripotent stem cells to an 8-cell embryo-like stage. Nature, 605, 315-324. (影响因子 = 56.7). ^#第一作者, *通讯作者。

2.         Jing Cao^#, Wenjuan Li^#, Jie Li^#, Md. Abdul Mazid^#, Chunyang Li^#, Yu Jiang^#, Wenqi Jia^#, Zhaodi Liao, Shiyu Sun, Jiqiang Fu, Yan Wang, Yong Lu, Yuting Xu, Yanhong Nie, Xinyan Bian, Changshan Gao, Xiaotong Zhang, Liansheng Zhang, Yunpan Li, Lixin Fu, Hao Liu, Junjian Lai, Yang Wang, Yue Yuan, Yiwei Lai, Longqi Liu, Xiaolong Wang, Qiang Sun*, Miguel A. Esteban*, Zhen Liu* (2023). Live Birth of Chimeric Macaque Monkey with High Contribution from Homologous Embryonic Stem Cells. Cell, (影响因子 = 50.7). ^#第一作者, *通讯作者。

3.       Yueli Yang^#, Wenqi Jia^#, Zhiwei Luo, Hao Liu, Yunpan Li, David P. Ibañez, Jinxiu Li, Yu Jiang, Lixin Fu, Junjian Lai, Liang Wu, Yiwei Lai, Longqi Liu, Miguel A. Esteban*, Md. Abdul Mazid*, Wenjuan Li* (2024). VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification. Nature Communications, 15(1)(2024). (影响因子 = 18.9). ^#第一作者, *通讯作者。

4.        Md. Abdul Mazid^#*, Yunpan Li^#, Mindie Zhao^#, Lixin Fu, Hao Liu, Yu Jiang, Wenqi Jia, Junjian Lai, Jinxiu Li, Haiwei Li, Babangida Jabir Saeed, Amash Manzoor, Zhiwei Luo, Yiwei Lai, Liang Wu, Yi Zou, Chaiyaboot Ariyachet, Carl Ward, Chuanyu Liu, Longqi Liu, Miguel A. Esteban*, Wenjuan Li* (2026). Generation of eight-cell embryo-like cells from human pluripotent stem cells. Nature Protocol, (影响因子 = 18.4). ^#第一作者, *通讯作者。

5.       Mazid Md. Abdul^#, David P. Ibañez, Ping Zhao, Hao Liu, Xiaofen Zhong, Yingying Li, Meng Zhang, Wenjuan Li, Yunpan Li, Carl Ward, Shuhan Chen, Dongye Wang, Baoming Qin, Miguel A. Esteban, Xiwei Wang*, Wenxia Fan*, Zhiwei Luo (2019). Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson's disease patient with mutant PINK1 (p. I368N). Stem Cell Research, 41. (影响因子 =0.8). ^#第一作者, *通讯作者。

6.      Juan Zhang^#*, Lamisa Ataei, Kirti Mittal, Liang Wu, Lauren Caldwell, Linh Huynh, Shahil Sarajideen, Kevin Tse, Marie-Michelle Simon, Md. Abdul Mazid, David P. Cook, Daniel Trcka, Tony Kwan, Michael M. Hoffman, Jeffrey L. Wrana, Miguel A. Esteban, Miguel Ramalho-Santos* (2025). LINE1 and PRC2 control nucleolar organization and repression of the 8C state in human ESCs. Developmental Cell, 60(2), 186-203. (影响因子 = 11.9). #第一作者, *通讯作者。

7.      Jie Li^#, Qingyuan Zhu^#, Jing Cao^#, Ying Liu^#, Yong Lu^#, Yining Sun, Qian Li, Yiming Huang, Shenshen Shang, Xinyan Bian, Chunyang Li, Liansheng Zhang, Yan Wang, Yanhong Nie, Jiqiang Fu, Wenjuan Li, Md. Abdul Mazid, Yu Jiang, Wenqi Jia, Xiaolong Wang, Yidi Sun, Miguel A. Esteban, Qiang Sun*, Fan Zhou*, Zhen Liu* (2023). Cynomolgus monkey embryo model captures gastrulation and early pregnancy, Cell Stem Cell, 30(4), 362-377. (影响因子 = 24.4). #第一作者, *通讯作者。

8.      Jiaowei Wang^#, Wenguang Xie^#, Nan Li^#, Wenjuan Li^#, Zhishuai Zhang^#, Nana Fan, Zhen Ouyang, Yu Zhao, Chengdan Lai, Hao Li, Mengqi Chen, Longquan Quan, Yunpan Li, Yu Jiang, Wenqi Jia, Lixin Fu, Md. Abdul Mazid, Yanling Zhu, Patrick H. Maxwell, Guangjin Pan*, Miguel A. Esteban*, Zhen Dai*, and Liangxue Lai*. Generation of a Humanized Mesonephros in Pigs from Induced Pluripotent Stem Cells via Embryo Complementation. Cell Stem Cell, 30, 1235-1245.e6. (影响因子 =24.4). ^#第一作者, *通讯作者。

9.      Isaac A. Babarinde, Gang Ma, Yuhao Li, Boping Deng, Zhiwei Luo, Hao Liu, Mazid Md. Abdul, Carl Ward, Minchun Chen, Xiuling Fu, Liyang Shi, Martha Duttlinger, Jiangping He, Li Sun, Wenjuan Li, Qiang Zhuang, Guoqing Tong, Jon Frampton, Jean-Baptiste Cazier, Jiekai Chen, Ralf Jauch, Miguel A. Esteban and Andrew P. Hutchins (2021). Transposable element sequence fragments incorporated into coding and noncoding transcripts modulate the transcriptome of human pluripotent stem cells. Nucleic Acids Research, 49(16). (影响因子 = 17.6). ^#第一作者, *通讯作者。

10.   Li Chen, Qiaoqiao Tong, Xiaowen Chen, Penglei Jiang, Hua Yu, Qianbing Zhao, Lingang Sun, Chao Liu, Bin Gu, Yuping Zheng, Lijiang Fei, Xiao Jiang, Wenjuan Li, Giacomo Volpe, Mazid MD. Abdul, Guoji Guo, Jin Zhang, Pengxu Qian, Qiming Sun, Dante Neculai, Miguel A. Esteban, Chen Li, Feiqiu Wen and Junfeng Ji (2021). PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus. Nature Communications, 12(1). (影响因子 = 18.9). ^#第一作者, *通讯作者。

11.   Zhang M, Lai Y, Krupalnik V, Zhou J, Guo P, Xu Y, Yu Z, Guo X, Liu L, Li W, Abdul M M, Ma G, Li N, Fu X, Lv Y, Wang L, Tariq M, Luo Z, Zhang H, Huang Y, Qin X, Chen S, Wang D, Ward C, Zhang X, He M, Ibañez DP, Liu H, Li Y, Kanwal S, Zhou J, Feng Y, Di Vicino U, Bao X, Wu G, Schambach A, Wang H, Gao F, Qin B, Hutchins AP, Hartmann C, Cosma MP, Yan Q, Chen R, Volpe G, Hanna JH, and Esteban MA (2020). β-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus. Science Advances, 6(29). (影响因子  = 14.8).  ^#第一作者, *通讯作者。

12.  He, J, Fu, X, Zhang, M, He, F, Li, W, Abdul, M. M, Zhou, J, Sun, L, Chang, C, Li, Y, Liu, H, Wu, K, Babarinde, I. A, Zhuang, Q, Loh, Y. H, Chen, J, Esteban, M. A, … Hutchins, A. P. (2019). Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells. Nature Communications, 10(1), 34. (影响因子  = 18.9). ^#第一作者, *通讯作者。

13.  Zhuang Qiang, Li Wenjuan, Benda Christina, Huang Zhijian, Ahmed Tanveer, Liu Ping, Guo Xiangpeng, Ibañez David P, Luo Zhiwei, Zhang Meng, Abdul Mazid Md, Yang Zhongzhou, Yang Jiayin, Huang Yinghua, Zhang Hui, Huang Dehao, Zhou Jianguo, Zhong Xiaofen, Zhu Xihua, Fu Xiuling, Fan Wenxia, Liu Yulin, Xu Yan, Ward Carl, Khan Muhammad Jadoon, Kanwal Shahzina, Mirza Bushra, Tortorella Micky D, Tse Hung-Fat, Chen Jiayu, Qin Baoming, Bao Xichen, Gao Shaorong, Hutchins Andrew P, Esteban Miguel A, (2018). NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming. Nature Cell Biology, 20, 400-412. (影响因子  = 23.0). ^#第一作者, *通讯作者。

国际学术会议报告

1.     2023年12月，在新加坡干细胞学会（SCSS）主办的第15届新加坡干细胞学会研讨会报告， 主题为：干细胞研究与医疗创新

2.     2024年6月，应日本熊本大学Hiroaki Okae教授邀请，在熊本大学分子胚胎学与遗传学研究 所做线上报告，主题为：From Decay to Renewal: Harnessing the Potentials of Human Totipotent and Pluripotent Cells for Rejuvenation

    专利申请国：国际

1. Miguel. A. Esteban, Mazid M.      Abdul, Li Wenjuan, Luo Zhiwei, Carl Ward, Li Yunpan, Lai Yiwei.      Media and Methods for Establishing and Maintaining Early Embryo-Like      Cells. 专利申请国: 国际 专利. 申请号:PCT/CN2020/128091. 专利申请日: 2020.11.11. 排序: 2/7. (申请中).
2. Miguel. A. Esteban, Yiwei Lai, Mazid M. Abdul, Jinxiu Li, Wenqi Jia, Lixin Fu, Jing Zuo,      Wenjuan Li, Wu Liang. EMBRYO-LIKE MODEL, AND CONSTRUCTION METHOD THEREFOR      AND USE THEREOF. 专利申请国：国际. 申请号: PCT/CN2023/118079. 专利申请日: 2023.09.01. 排 序: 3/7. (申请中).
3. Miguel. A. Esteban, Wenjuan Li, Mazid M. Abdul, Yu Jiang, Yiwei Lai, Zhiwei Luo, Jinxiu Li.      Media and Methods for Producing Human Cells and Tissues from Teratoma,      Organoids and Embryoid Bodies.专利申请国: 国际专利. 申请号: PCT/CN2022/081499. 专利申请日: 2022.10.26. 排序: 3/7. (申请中).

专利申请国：中国

4. 穆罕默德·阿卜杜尔·马西德,姜禹,陈健,李海威,邹易,黎运盼,刘真; 基于猴原始态多能干细胞 定向诱导为下胚层样细胞的培养基及培养方法, 专利申请国:中国. 申请号: 202610502121.9. 专 利申请日: 2026.04.16. 排序: 1/7. (申请中).
5. 穆罕默德·阿卜杜尔·马西德, 姜禹, 李海威, 刘传宇, 巴班吉达·贾比尔·赛义德, 邹易, 陈健, 基于原始态多能干细胞定向诱导为羊膜样细胞的培养基及培养方法, 专利申请国:中国. 申请 号: 202610213414.5. 专利申请日:      2026.02.13. 排序: 1/7. (申请中).

6.     Miguel. A. Esteban, Mazid M. Abdul, Li Wenjuan, Luo Zhiwei, Carl Ward, Li Yunpan, Lai Yiwei.建立和维持早期胚胎样细胞的培养基和方法. 专利申请国: 中国. 申请号: 202011256758.3. 专利申请日: 2020.11.11.  排序: 2/7. (申请中).

7.     Miguel. A. Esteban, Wenjuan Li, Mazid M. Abdul, Yu Jiang, Yiwei Lai, Zhiwei Luo, Jinxiu Li. 从 畸胎瘤、类器官和拟胚体中产生人细胞和组织的培养基和方法. 专利申请国: 中国. 申请号: 202211317527.8. 专利申请日: 2022.10.26. 排序: 3/7. (申请中).