2017年博士毕业于中国科学院广州生物医药与健康研究院，同年12月赴美国Fox Chase Cancer Center开展博士后研究，2024年晋升为该中心研究助理教授。2026年4月受聘于中国科学院广州生物医药与健康研究院，任脑肿瘤发病机理与治疗研究课题组长，PI研究员。

参与多项科研项目，包括美国国立卫生研究院（NIH）、美国癌症协会（ACS）、佛罗里达州卫生部等机构资助的课题。至今已发表SCI论文15篇以上，其中包括《Cancer Cell》、《Molecular Therapy Oncology》、《Cell Death & Differentiation》等权威期刊。兼任美国癌症研究协会（AACR）、神经肿瘤学会（SNO）、甲状腺协会（ATA）及国际细胞外囊泡学会（ISEV）会员。目前担任Oncogene，Neuro-Oncology，Cancers，STAR Protocols等期刊审稿人。

1. 儿童脑肿瘤细胞分化机理及治疗策略

2. 肿瘤脑转移发生机制研究

3. 基于细胞外囊泡的脑肿瘤分子诊断与分子分型研究

1. Yang, YJ., Valdes-Rives, S. A., Liu, Q., Li, Y., Tan, J., ... & Yang Z-J. Thyroid Hormone Suppresses Medulloblastoma Progression Through Promoting Terminal Differentiation of Tumor Cells. Cancer Cell. 2024;42(8):1434-49.

---Highlighted by Vijay Ramaswamy, Leading medulloblastoma to a differentiation end. Cancer Cell.  2024;42(8):1331-3.

2. Valdes-Rives, S. A., Yang YJ*, Yang Z-J*. Protocol to monitor cardiovascular effects of triiodothyronine in tumor-bearing mice via non-invasive electrocardiogram recordings. STAR protocols. 2025 Sep 19;6(3):103900. (* Correspondence)

3. Yang YJ, Ronsley R, Sarah Leary S,Kilburn L, Kim A, Wechsler-Reya R.J, Yang Z-J. Repurposing Thyroid Hormone to Improve Chemotherapy Outcome for Medulloblastoma. Molecular Therapy Oncology. 2026 (Accepted)

4. Heller A, Du F, Liu YQ, Yang YJ*, Yang Z-J*. Generating a Mouse Model for Relapsed SHH-Group Medulloblastoma. STAR protocols. 2023;4(2):102234. (* Correspondence)

5. Zhang J, Yang YJ et al. PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating ciliary formation. Cell Death & Differentiation. 2023; 30.5, 1198-1210.

6. Yang YJ, Qu YH, Cheng Y, Guo D, Fan Q, Yang Z-j. Purification of differentiated tumor cells from medulloblastoma for transplantation into mouse cerebellum. STAR Protocols. 2021;2(2):100409.

7. Wang Q, Wu H, Hu J, Fu H, Qu Y, Yang YJ, et al. Nestin Is Required for Spindle Assembly and Cell-Cycle Progression in Glioblastoma Cells. Molecular Cancer Research.2021; 19.10: 1651-1665.

8. Guo, DC., Qu, YH., Yang, YJ., Yang, ZJ. Medulloblastoma cells resemble neuronal progenitors in their differentiation. Molecular & Cellular Oncology 2020; 7.6: 1810514

9. Lu, J., Tong, Y., Dong, R., Yang, YJ., Hu, W., Zhang, M., ... & Chen, X. Large DNA fragment knock-in and sequential gene editing in Plasmodium falciparum: a preliminary study using suicide-rescue-based CRISPR/Cas9 system. Molecular and Cellular Biochemistry, 2024; 479(1), 99-107.

10. Adah, D., Yang, YJ., Liu, Q. et al. Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model. Cell Commun Signal 17, 32 (2019).

11. Yang, YJ., Liu, Q., Lu JN., Adah, D., Yu, SL., Zhao, ST., Yao, YC., Qin, L, Qin, LM and Chen,XP. Exosomes from Plasmodium-infected hosts inhibit tumor angiogenesis in a murine Lewis lung cancer model. Oncogenesis. 2017; 6, e351

12. Liu, Q., Yang, YJ., Tan, X., Tao, Z., Adah, D., Yu, S., Lu, J., Zhao, S., Qin, L., Qin, L., & Chen, X. Plasmodium parasite as an effective hepatocellular carcinoma antigen glypican-3 delivery vector. Oncotarget, 2017;8(15):24785-24796.

13. Yu, S., Yao, Y., Xiao, H., Li, J., Liu, Q., Yang, YJ., Adah, D., Lu, J., Zhao, S., Qin, L., Chen X.(2017). Simultaneous knockout of CXCR4 and CCR5 genes in CD4+ T cells via CRISPR/Cas9 confers resistance to both X4- and R5-tropic HIV-1 infection. Hum Gene Ther.2017.032

14. Reiner, A. T., Witwer, K. W., van Balkom, B. W.M., de Beer, J., Brodie, C., Corteling, R. L., Gabrielsson, S., Gimona, M., Ibrahim, A. G., de Kleijn, D., Lai, C. P., Lötvall, J., del Portillo, H.A., Reischl, I. G., Riazifar, M., Salomon, C., Tahara, H., Toh, W. S., Wauben, M. H.M., Yang, V.K., Yang, YJ., Yeo, R. W. Y., Yin, H., Giebel, B., Rohde, E. and Lim, S. K. (2017), Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles. STEM CELLS Translational Medicine.

15. Lu, J., Tong, Y., Pan, J., Yang, YJ., Liu, Q., Tan, X., ... & Chen, X. (2016). A redesigned CRISPR/Cas9 system for marker-free genome editing in Plasmodium falciparum. Parasites & vectors. 2016; 9(1), 1.

16. Adah, D., Yang, YJ, Liu, Q., et al. Pre-erythrocytic stage of malaria infection and the molecular targets available for interventions[J]. J. Adv. Parasitol. 2016; 3(4): 132-141.

专利:

1. Yang, Zengjie, and Yang Yijun. Methods of treating medulloblastoma with thyroid hormone. WO2024064807A3.

2. Yang, Zengjie, and Yang Yijun. Exosome analysis and brain tumors. WO2021216733A2.

3. Chen Xiaoping, Yang Yijun, Qin li. Exosome, preparation method therefor and use thereof in preparing anti-tumor drug or preparation. WO2019114148A1.