教育背景

2014 - 2018

比利时鲁汶大学（KU Leuven）医学院肿瘤学系 生物医学博士（PhD）

2008 - 2011

中国科学院水生生物研究所 遗传学硕士

2004 - 2008

安徽师范大学 理学学士

工作经历

2026年5月至今

中国科学院广州生物医药与健康研究院 研究员

2023 - 2026

宾夕法尼亚大学医学院 心血管研究所 & 医学系  副研究员

2018 - 2023

宾夕法尼亚大学医学院 心血管研究所 & 医学系 博士后

2014 - 2018

比利时鲁汶大学 VIB癌症生物学研究中心 博士研究生

2012 - 2013

中国科学院水生生物研究所 研究助理

2008 - 2011

中国科学院水生生物研究所 硕士研究生

2023   Gordon Research Conference（GRC）血管生成大会最佳墙报奖

2022   国际血管生物学大会（IVBM）差旅奖

2020 – 2021   美国心脏协会博士后奖学金

2014 – 2018  鲁汶大学博士奖学金

2008   安徽省优秀毕业生

2008   安徽师范大学“朱敬文”一等奖学金

2006、2007 安徽师范大学三好学生标兵

2005、2008安徽师范大学三好学生

发表文章

Derek C. Sung, Hana Ahanger, Sweta Narayan, Jesse Pace, Mei Chen, Jisheng Yang, Siqi

Gao, TC Stevenson Keller IV, Jenna Bockman, Xiaowen Chen, Erica Ngyuen, Alan T. Tang,

Patricia Mericko, Ivan P. Maillard, Mark L. Kahn. Dll4 assembles the umbilical cord and

placental vasculature. JCI Insight. 

Jesse Pace, Lauren Goddard, Courtney Hong, Liqing Wang, Jisheng Yang, Mei Chen, Yitian

Xu, Martin Dominguez, Siqi Gao, Xiaowen Chen, Patricia Mericko, Wenbao Yu, Kai Tan,

Wayne Hancock, Giovanni Ferrari, Mark L. Kahn. Hemodynamic forces prevent myxomatous

valve disease through KLF2/4 signaling. Journal of Clinical Investigations. 2025. In press

Xiaowen Chen, Joanna Tober, Martin Dominguez, Alan T. Tang, Jenna Bockman, Chin Nien

Lee, Jisheng Yang, Mei Chen, Patricia Mericko-Ishizuka, Nancy A. Speck, Mark L. Kahn.

Genetic lineage tracing reveals that the murine placenta is not a de novo source of

hematopoietic stem cells. PLoS Biology, 2025.

Siqi Gao, Triloshan Thillaikumaran, Martin H. Dominguez, William Giang, Kevin Hayes,

Xiaowen Chen, Jesse Pace, Jenna Bockman, Danielle Jathan, Derek Sung, Sweta

Narayan, Maxwell Frankfurter, Mei Chen, Patricia Mericko-Ishizuka, Jisheng Yang, Marco

Castro, Michael Potente, Mark L. Kahn. YAP/TAZ signaling in allantois-derived cells is required

for placental vascularization. Biorxiv

Siqi Gao, Alan T Tang, Min Wang, David W Buchholz, Brian Imbiakha, Jisheng Yang, Xiaowen

Chen, Peter Hewins, Patricia Mericko-Ishizuka, N Adrian Leu, Stephanie Sterling, Avery

August, Kellie Jurado, Edward Morrisey, Hector Aguilar-Carreno, Mark L Kahn. Endothelial

SARS-CoV-2 infection is not the underlying cause of COVID19-associated vascular pathology in

mice. Frontier in Cardiovascular Medicine, 2023.

Xiaowen Chen, Alan T. Tang, Joanna Tober, Jisheng Yang, N. Adrian Leu, Stephanie Sterling,

Mei Chen, Yiqing Yang, Patricia Mericko-Ishizuka, Nancy A. Speck, Mark L. Kahn. Mouse

placenta fetal macrophages are tissue resident macrophages that arise from endothelial cells

outside the placenta. Developmental Cell. 2022. Doi: 10.1016/j.devcel.2022.11.003.

Derek C. Sung, Mei Chen, Martin H. Dominguez, Aparna Mahadevan, Xiaowen Chen, Jisheng

Yang, Siqi Gao, Aileen A. Ren, Alan T. Tang, Patricia Mericko, Raiyah Patton, Michelle Lee,

Melanie Jannaway, Astrid Nottebaum, Dietmar Vestweber, JoshuaP. Scallan, and Mark L.

Kahn. Sinusoidal and lymphatic vessel growth are controlled byreciprocal VEGF-C–CDH5

inhibition. Nature Cardiovascular Research. 2022. Doi: 10.1038/s44161-022-00147-0

Suhee Chang, Diana Fulmer, Stella K Hur, Joanne L Thorvaldsen, Li Li, Yemin Lan, Eric A

Rhon-Calderon, Xiaowen Chen, Jonathan A Epstein, Marisa S Bartolomei. Dysregulated

H19/Igf2 expression disrupts cardiac-placental axis during development of Silver Russell

Syndrome-like mouse models., eLife, 2022. Doi: 10.7554/eLife.78754

Derek C Sung, Xiaowen Chen, M Chen, J Yang, S Schultz, A Babu, Y Xu, TCS Keller IV, P

Mericko, JP Scallan, and Mark L. Kahn. VE-cadherin enables trophoblast endovascular invasion

and spiral artery remodeling during placental development. eLife, 2022. Doi:

10.7554/eLife.77241

Yiqing Yang, Melanie Mumau, Laura Bennet, Yasin Uzun, Joanna Tober, Peng Gao, Courtney

Hong, Swapnil Shewale, Mei Chen, Jisheng Yang, Xiaowen Chen, Steven A. Thomas, Kai Tan,

Nancy A. Speck, and Mark L. Kahn. Endothelial MEKK3-KLF2/4 signaling integrates cytokine

and hemodynamic signals during definitive hematopoiesis. Blood, 2022. Doi:

10.1182/blood.2021013934

Louw J*, Bastos R*, Xiaowen Chen*, Verdood C, Corveleyn A, Jia Y, Breckpot J, Gewillig M,

Peeters H, Santoro MM; Barr F, Devriendt K. Compound heterozygous loss-of-function

mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two

siblings. PLoS Genetics, 2018. Doi: 10.1371/journal.pgen.1007138

Xiaowen Chen*, Dafne Gays*, Carlo Milia, Massimo M Santoro. Cilia control vascular mural cell

recruitment in vertebrates. Cell Reports. 2017

Song G, Han M, Li Z, Gan X, Xiaowen Chen, Yin Z, Zheng F. Deletion of Pr72 causes cardiac

developmental defects in Zebrafish. PloS One, 2018. doi: 10.1371/journal.pone.0206883

Peng X*, Shang G*, Wang W*, Xiaowen Chen, Lou Q, Zhai G, Li D, Du Z, Ye Y, Jin X, He J,

Zhang Y, Yin Z. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by

1α,25(OH)(2)D(3). Cell Reports. 2017. Doi: 10.1016/j.celrep.2017.04.066.

Xiaowen Chen, Gays D, Santoro MM. Transgenic Zebrafish. Methods Mol Biol. 2016;1464:107-

114.

Xia Y, Xiaowen Chen, He J, Liu J, Yin Z. Endocrine gene expression patterns associated with

the ovarian maturation of wild female largemouth bronze gudgeon (Coreius Guichenoti). Acta

Hydrobiologica Sinica. 2016. Doi: 10.7541/2016.58

Dai X, Jin X, Xiaowen Chen, He J, Yin Z. Sufficient numbers of early germ cells are essential

for female sex development in zebrafish. PLoS One. 2015. Doi: 10.1371/journal.pone.0117824.

Cheng X, Xiaowen Chen, Li D, Jin X, He J, Yin Z. Effects of metronidazole on

proopiomelanocortin a gene expression in zebrafish. Gen Comp Endocrinol. 2015. Doi:

10.1016/j.ygcen.2014.05.029.

Cheng X, Xiaowen Chen, Jin X, He J, Yin Z. Generation and characterization of Gsu

alpha:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. Toxicol Appl

Pharmacol. 2014. Doi: 10.1016/j.taap.2014.04.009.

He W, Dai X, Xiaowen Chen, He J, Yin Z. Zebrafish pituitary gene expression before and after

sexual maturation. J Endocrinol. 2014. Doi: 10.1530/JOE-13-0488.

Li D, Lou Q, Zhai G, Peng X, Cheng X, Dai X, Zhuo Z, Shang G, Jin X, Xiaowen Chen, Han D,

He J, Yin Z. Hyperplasia and cellularity changes in IGF-1-overexpressing skeletal muscle of

crucian carp. Endocrinology. 2014. Doi: 10.1210/en.2013-1938.

Zhai G, Gu Q, He J, Lou Q, Xiaowen Chen, Jin X, Bi E, Yin Z. Sept6 is required for ciliogenesis

in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development.

Mol Cell Biol. 2014. Doi: 10.1128/MCB.01409-13.

Xiaowen Chen, Lou Q, He J, Yin Z. Role of zebrafish lbx2 in embryonic lateral line

development. PLoS One. 2011. Doi: 10.1371/journal.pone.0029515.

专利

1. 一种靶向淋巴系统的抗凝剂用于预防淋巴血栓形成

专利号：PCT/US23/028994

发明人：Mark L. Kahn，John Welsh，陈晓文，Jacob Myerson

2. 一种病理性血管生成抑制剂及其用途

中国专利号：2021100638262

发明人：陈晓文