RNA与RNA结合蛋白的相互作用在基因表达调控中的机理研究，非编码RNA以及RNA结合蛋白在肿瘤中的功能以及作用机制研究。

招生方向：

生物化学与分子生物学
细胞生物学
化学生物学

1. Menghui Yin (尹梦回）#*, Meidie Cheng#, Chengli Liu#, Keli Wu, Wei Xiong, Ji Fang, Yinxiong Li, Biliang Zhang*. HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6. iScience. 2021, 24(11), 103345,DOI:10.1016/j.isci.2021.103345.
2. Tingting Xu#*, Qingqing Gan, Bin Wu, Menghui Yin(尹梦回）, Jinxin Xu, Xiaodong Shu and Jinsong Liu*. Molecular Basis for PI(3,5)P2 Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation. Journal of Molecular Biology. 2020 Jul 24;432(16):4750-4761.  
3. Linlin Hou*, Yuanjie Wei, Yingying Lin, Xiwei Wang, Yiwei Lai, Menghui Yin (尹梦回）,Yanpu Chen, Xiangpeng Guo, Senbin Wu, Yindi Zhu, Jie Yuan, Muqddas Tariq, Na Li, Hao Sun, Huating Wang, Xiaofei Zhang, Jiekai Chen, Xichen Bao*, Ralf Jauch*. Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2. Nucleic Acids Research. 2020, 2(3).
4. Xichen Bao#*, Xiangpeng Guo# , Menghui Yin# (尹梦回）, Muqddas Tariq, Yiwei Lai, Shahzina Kanwal, Jiajian Zhou, Na Li, Yuan Lv, Carlos Pulido-Quetglas, Xiwei Wang, Lu Ji, Muhammad J Khan, Xihua Zhu, Zhiwei Luo, Changwei Shao, Do-Hwan Lim , Xiao Liu, Nan Li, Wei Wang, Minghui He, Yulin Liu, Carl Ward, Tong Wang, Gong Zhang, Dongye Wang, Jianhua Yang, Yiwen Chen, Chaolin Zhang, Ralf Jauch, Yungui Yang, Yangming Wang, Baoming Qin, Minna-Liisa Anko, Andrew P Hutchins, Hao Sun, Huating Wang, Xiang-Dong Fu, Biliang Zhang*, Miguel A Esteban*. " Capturing the interactome of newly transcribed RNA. Nature Methods. 2018 Mar;15(3):213-220.
5. Menghui Yin (尹梦回）#, Xiaoshuai Ren #, Zhang Xin, Luo Yingjun, Wang Guoxin, Huang Kaili, Feng Shipeng, Bao Xicheng, Huang Ke, He Xiaoping, Liang Peizhou, Wang Zhe, Tang Hailing, He Jianxing*, Zhang Biliang*. Selective killing of lung cancer cells by miRNA-506 molecule through inhibiting NF-κB p65 to evoke reactive oxygen species generation and p53 activation. Oncogene. 2015, 34(6):691  
6. Xiaoshuai Ren, Menghui Yin (尹梦回）, Xin Zhang, Zhe Wang, Shipeng Feng, Guoxin Wang,   Yingjun Luo, Peizhou Liang, Xiuqun Yang, Jianxing He* and Biliang Zhang*, Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells. Cancer Letters. 2014,344(2),195-203,
7. Xichen Bao*, Haitao Wu, Xihua Zhu, Xiangpeng Guo, Andrew P Hutchins, Zhiwei Luo, Hong Song  , Yongqiang Chen, Keyu Lai, Menghui Yin (尹梦回）, Lingxiao Xu, Liang Zhou, Jiekai Chen, Dongye Wang , Baoming Qin, Jon Frampton, Hung-Fat Tse, Duanqing Pei, Huating Wang, Biliang Zhang, Miguel A Esteban*. The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. Cell Research. 2015. 25. 80-92.
8. Shipeng Feng, Shujie Cong, Xin Zhang, Xichen Bao, Wei Wang, Huiping Li, Zhe Wang, Guoxin Wang, Jianzhen Xu, Bowen Du, Dezhong Qu, Wei Xiong, Menghui Yin (尹梦回）, Xiaoshuai Ren, Feifei Wang, Jianxing He and Biliang Zhang. MicroRNA-192 targeting retinoblastoma 1 (RB1) inhibits cell proliferation and induces cell apoptosis in lung cancer cells. Nucleic Acids Research. 2011(39): Issue 15 Pp. 6669-6678.
9. Yuehua Xiao, Menghui Yin(尹梦回）, Lei Hou, Yan Pei*. Direct amplification of intron-containing hairpin RNA construct from genomic DNA. Biotechniques. 2006 Nov;41(5):548, 550, 552.
10. Yuehua Xiao, Menghui Yin(尹梦回）, Lei Hou, Ming Luo, Yan Pei*. Asymmetric overlap extension PCR method bypassing intermediate purification and the amplification of wild-type template in site-directed mutagenesis.Biotechnology Letters. Volume 29, Number 6: 925-930,2007 

专利申请：

1. 一种捕获核酸结合蛋白的方法和试剂盒。申请号：201710080808.9。公开号：CN108427000A。公开日：2021.06.08。发明人：张必良，米格尔·埃斯特班，鲍习琛，郭亨彭，尹梦回，王玮，克雷格·梅洛。

2.  一种核酸分子及其应用。申请号：CN201210071712.3。公开号：CN102533770A。公开日：2012.07.04。发明人：张必良 ，尹梦回，冯世鹏，王玮，克雷格·梅洛。