主讲人：陈可实 副研究员

　　时间：2019年10月18日 15：30 

　　地点：第一会议室A430

　　主持人：郭宜平 副研究员

Achievement introduction: Chromatin relaxation is required for generation of pluripotent stem cells, but how factor‐dependent chromatin opening is instructed remains poorly understood. Here, epigenetic profiling reveals Oct4 as a pioneer factor that loosens heterochromatin and cooperates with Klf4 and other chromatin remodellers during reprogramming.