
以冷冻电镜和X-射线晶体学为主要手段,综合运用各种生物化学、生物物理和细胞生物学方法,研究:
◦ 光合微生物的电子传递与能量代谢机制,及其在人工光合作用和合成生物学中的应用;
◦ 重要生物大分子(电子传递链膜蛋白复合物、酶)的结构与功能;
◦ 蛋白质(酶)分子的半合理设计及其在医药中间体合成中的应用。
主持国家自然科学基金项目 6 项,浙江省自然科学基金杰出青年及其延续项目等 3 项,省级人才项目 2 项,杭州市重中之重实验室经费 1 项,横向课题 1 项,校级经费 3 项:
1. 国家自然科学基金面上项目:光合玫瑰菌 ATP 合酶的结构和作用机制 (32471270),2025-2028年,50 万元,主持,在研;
2. 国家自然科学基金国际(地区)合作与交流项目:探索早期原核光合生物光系统的膜组织和电子传递机制(W2421043),2025-2026 年,10 万元,主持,在研;
3. 浙江省自然科学基金杰出青年延续项目:光合玫瑰菌天然光合膜的结构和光合电子传递链的体外组装(LRG26C020001),2026-2028 ,80 万元,主持,在研;
4. 国家 自然科学基金面上项 目 : 替代复合体 III 在光合和呼吸电子传递链中的作用机制(32171227),2022-2025 年,58 万元,主持,资助期满;
5. 国家自然科学基金面上项目:光合玫瑰菌三羟基丙酸循环固碳途径的分子机制(31870740), 2019-2022 年,65 万元,主持,结题;
6. 国家自然科学基金面上项目:光合玫瑰菌核心光合复合体的结构与功能研究(31570738), 2016-2019 年,62 万元,主持,结题;
7. 国家自然科学基金青年项目:色氨酰 tRNA 合成酶抑制新血管生成的分子机制(31400630), 2015-2017 年,25 万元,主持,结题;
8. 浙江省自然科学基金杰出青年项目:光合玫瑰菌的电子传递调控与产氢(LR22C020002), 2022-2024 年,80 万元,主持,结题;
9. “杭州市创新药物研究 ” 重中之重实验室项目,2014-2017 年,48 万元,主持,结题;
10. 杭州师范大学交叉学科创新研究项目:基于细菌光合作用构建人工光合细胞的先导研究, 2024-2028 ,100 万元,主持,在研。
2023 年 浙江省“三育人” 岗位建功活动先进个人
2021 年 浙江省高层次人才特殊支持计划青年拔尖人才
2021 年 杭州市教育局系统优秀教师
2019 年 浙江省“院士结对培养青年英才”
2019 年 国家科技进步二等奖:“新型稀缺酶资源研发体系创建及其在医药领域应用”(10/10)
2017 年 杭州市“西湖学者”、“131”中青年人才培养计划第一层次
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