| 论文编号: |
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| 第一作者所在部门: |
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| 中文论文题目: |
Palladium-catalyzed alkyne hydrocarbonylation under atmospheric pressure of carbon monoxide in the presence of hydrosilane |
| 英文论文题目: |
Palladium-catalyzed alkyne hydrocarbonylation under atmospheric pressure of carbon monoxide in the presence of hydrosilane |
| 作者: |
Luo, Yu; Wang, Xilong; Liu, Qianwen; He, Yimiao; Li, Jing; Luo, Shuang; Zhu, Qiang |
| 论文出处: |
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| 刊物名称: |
GREEN CHEMISTRY |
| 年: |
2023 |
| 卷: |
25 |
| 期: |
3 |
| 页: |
1120-1127 |
| 联系作者: |
Zhu, Qiang |
| 收录类别: |
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| 影响因子: |
11.034 |
| 摘要: |
An ultramild reaction condition for the hydrocarbonylation of alkynes, which is performed under atmospheric pressure of CO in the absence of acids, has been developed. Palladium hydride (Pd-H) generated from triethylsilane (Et3SiH) rather than the traditionally used strong acid (HX) is applied for the first time in this transformation. In addition, an unusual counteranion-controlled linear and branch selectivity for terminal alkynes is observed under otherwise identical conditions. A wide range of 1,1-, 1,2-, and 1,2,2-substituted alpha,beta-unsaturated thioesters or amides are regioselectively obtained from terminal and internal alkynes in moderate to excellent yields. Furthermore, the first enantioselective construction of indolone derivatives with a C-N chiral axis is achieved when using 2-(tert-butyl)-N-(2-alkynylphenyl)aniline as the substrate in the presence of TMS-SYNPHOS as the chiral ligand. |
| 英文摘要: |
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