首页 >> 资源库 >> 中文 >> 论文

论文

论文编号:
第一作者所在部门:
中文论文题目: Parallel Kinetic Resolution through Palladium-Catalyzed Enantioselective Cycloimidoylation: En Route to Divergent N-Heterocycles Bearing a Quaternary Stereogenic Center
英文论文题目: Parallel Kinetic Resolution through Palladium-Catalyzed Enantioselective Cycloimidoylation: En Route to Divergent N-Heterocycles Bearing a Quaternary Stereogenic Center
作者: Xilong Wang, Yu Luo, Jing Li, Chaoqin Wang, Qianwen Liu, Yimiao He, Shuang Luo* and Qiang Zhu
论文出处:
刊物名称: ACS Catalysis
年: 2022
卷: 12
期:
页: 14918-14925
联系作者: Qiang Zhu
收录类别:
影响因子: 13.700
摘要:  An example of a parallel kinetic resolution catalyzed by palladium to produce enantioenriched five- and six-membered N-heterocycles in one pot was developed. Dihydroisoquinolines and 1H-isoindoles containing a quaternary stereogenic center were obtained from racemic isocyanides in high yields with good enantioselectivities under mild conditions. A 6,6′-dipropyl substituted SPINOL-derived phosphoramidite was used as the chiral ligand for the palladium catalyst, resulting in regiodivergent and stereospecific cycloimidoylation. Density functional theory (DFT) calculations reveal the origin of the regio- and enantioselectivity during the C(sp2)?H imidoylative cyclization process. KEYWORDS: palladium catalysis, enantioselective imidoylation, parallel kinetic resolution, C?H activation, quaternary stereogenic center
英文摘要:
外单位作者单位:
备注: