| Transcription factor EB-mediated mesenchymal stem cell
therapy induces autophagy and alleviates spinocerebellar
ataxia type 3 defects in neuronal cells model |
Xiaobo Han, Jean de Dieu Habimana, Amy L. Li, Rongqi Huang, Omar Mukama, Weiyue Deng, Ling Wang, Yuying Zhang,
Wei Wang, Sihao Deng, Kexin Peng, Bin Ni, Shusheng Zhang, Jufang Huang, Xiao-xin Yan and Zhiyuan Li. |
2022 |
Cell Death & Disease |
| Subsequent malaria enhances virus-specific T cell immunity in SIV-infected Chinese rhesus macaques |
Guangjie Liu, Li Qin, Youjia Li, Siting Zhao, Mikhail Shugay, Yongxiang Yan, Yijian Ye, Yue Chen, Cuizhu Huang, Nashun Bayaer, Dickson Adah, Hui Zhang, Zhong Su, Xiaoping Chen. |
2022 |
Cell Communication and Signaling |
| H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition |
Runxia Lin, Ziwei Zhai, Junqi Kuang, Chuman Wu, Yuxiang Yao, Ruona Shi, Jiangping He, Shuyang Xu, Pengli Li, Yixin Fan , Wei Li , Zichao Wu, Xiaoxi Li, Jin Ming, Jing Guo, Bo Wang, Dongwei Li, Shangtao Cao, Xiaofei Zhang, Yi Li, Duanqing Pei, Jing Liu |
2022 |
Cell and Bioscience |
| A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism |
Muzammal Hussain, Yongzhi Lu, Muqddas Tariq, Hao Jiang, Yahai Shu, Shuang Luo, Qiang Zhu, Jiancun Zhang, and Jinsong Liu |
2022 |
iScience |
| Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors |
Zhiwu Jiang, Lin Cheng, Zhiping Wu, Linfu Zhou, Haitao Wang, Qilan Hong, Qiting Wu, Youguo Long, Yunlin Huang, Gaoqi Xu, Yao Yao, Zhao Yang Tang, Zhenfeng Zhang, Lili Yang, Wei Luo, Jie Yang, Likun Gong, Pentao Liu, Xinwen Chen, Shuzhong Cui, Qi Zhang, Yinxiong Li, Peng Li |
2022 |
EMBO reports |
| DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D |
Shanglin Li, Ruocong Zhao, Diwei Zheng, Le Qin, Yuanbin Cui, Yao Li, Zhiwu Jiang, Mengjun Zhong, Jingxuan Shi, Ming Li, Xindong Wang, Zhaoyang Tang, Qiting Wu, Youguo Long, Duo Hu, Suna Wang, Yao Yao, Shuang Liu, Li-Hua Yang, Zhenfeng Zhang, Qiannan Tang, Pentao Liu, Yangqiu Li, Peng Li |
2022 |
Molecular Therapy-Oncolytics |
| Insight into novel anti-tuberculosis vaccines by using immunoinformatics approaches |
Zafran Khan, Daniya Ualiyeva, Obed B. Amissah, Sanjeep Sapkota, H.M.Adnan Hameed, Tianyu Zhang |
2022 |
Frontiers in Microbiology |
| Hoxb5 reprogrammes murine multipotent blood progenitors into haematopoietic stem cell-like cells |
Dehao Huang, Qianhao Zhao,Mengyun Zhang,Qitong Weng,
Qi Zhang,Kaitao Wang,Fang Dong,Hui Cheng,Fangxiao Hu,Jinyong Wang |
2022 |
Cell Proliferation |
| The Chemokine Receptor CCR8 Is a Target of Chimeric Antigen T Cells for Treating T Cell Malignancies |
Diwei Zheng, Xindong Wang, Lin Cheng, Le Qin, Zhiwu Jiang, Ruocong Zhao, Yao Li, Jingxuan Shi, Qiting Wu, Youguo Long, Suna Wang, Zhaoyang Tang, Xinwen Chen, Yao Yao, Lihua Yang and Peng Li |
2022 |
Frontiers in Immunology |
| Discovery of a Highly Selective and H435R Sensitive Thyroid Hormone Receptor β Agonist |
Qiu Li#, Benqiang Yao#, Shiting Zhao, Zhou Lu, Yan Zhang, Qiuping Xiang, Xishan Wu, Haonan Yu, Cheng Zhang, Junhua Li, Xiaoxi Zhuang, Donghai Wu, Yong Li, Yong Xu |
2022 |
Journal of Medicinal Chemistry |
| C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction |
Lai, Peilong, Chen, Xiaomei, Wang, Yulian, Wang, Jinghua, Zhang, Yuchen, Geng, Suxia, Li, Peng, Du, Xin, Weng, Jianyu and Pei, Duanqing |
2022 |
Journal of hematology & oncology |
| AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns |
Yanhui Liang,Jingke Xie,Quanjun Zhang, Xiaomin Wang1,Shixue Gou1,Lihui Lin1,Tao Chen,Weikai Ge1,Zhenpeng Zhuang,Meng Lian,Fangbing Chen1, Nan Li,ZhenOuyang,Chengdan Lai,Xiaoyi Liu1,Lei Li1,Yinghua Ye,HanWu,Kepin Wang,Liangxue Lai |
2022 |
Nucleic Acids Research |
| BMP4 drives primed to na？ve transition through PGC-like state |
Shengyong Yu, Chunhua Zhou, Jiangping He, Zhaokai Yao, Xingnan Huang, Bowen Rong, Hong Zhu, Shijie Wang, Shuyan Chen, Xialian Wang, Baomei Cai, Guoqing Zhao, Yuhan Chen, Lizhan Xiao, He Liu, Yue Qin, Jing Guo, Haokaifeng Wu , Zhen Zhang, Man Zhang, Xiaoyang Zhao, Fei Lan, Yixuan Wang, Jiekai Chen, Shangtao Cao, Duanqing Pei, Jing Liu |
2022 |
Nature Communications |
| Generation of pigs with humanized type II collagen by precise human COL2A1 gene knock-in |
Ting Lan, Yuling Zheng, Yangyang Suo, Yuhui Wei, Hui Shi, Quanmei Yan,Zhenpeng Zhuang, Huangyao Chen, Quanjun Zhang, Nana Fan, Yu Zhao, Zhen Ouyang, Chengdan Lai, Zhaoming Liu, Jizeng Zhou, Chengcheng Tang, Nam-Hyung Kim, Qingjian Zou, Xiaomin Wang |
2022 |
Journal of Genetics and Genomics |
| Protocol for isolation and proteostatic analysis
of sub-populations of spermatogenic cells in
mouse |
Qianxing Zou, Lele Yang, Huayu Qi |
2022 |
STAR Protocols |
| Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells |
Yanling Zhu, Zhishuai Zhang, Nana Fan, Ke Huang, Hao Li, Jiaming Gu, Quanjun Zhang, Zhen Ouyang, Tian Zhang, Jun Tang, Yanqi Zhang, Yangyang Suo, Chengdan Lai, Jiaowei Wang, Junwei Wang, Yongli Shan, Mingquan Wang, Qianyu Chen, Tiancheng Zhou, Liangxue Lai, Guangjin Pan |
2022 |
Stem Cell Reports |
| MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening |
Guangsuo Xing, Zichao Liu, Luyuan Huang, Danyun Zhao, Tao Wang, Hao Yuan, Yi Wu, Linpeng Li, Qi Long, Yanshuang Zhou, Zhihong Hao, Yang Liu, Jianghuan Lu, Shiting Li, Jieying Zhu, Bo Wang, Junwei Wang, Jing Liu, Jiekai Chen, Duanqing Pei*, Xingguo Liu*, Keshi Chen* |
2022 |
Cell Death & Differentiation |
| Rolling back of human pluripotent stem cells to an 8-cell embryo-like stage |
Mazid, M.A., Ward, C., Luo, Z., Liu, C., Li, Y., Lai, Y., Wu, L., Li, J., Jia, W., Jiang, Y., Liu, H., Fu, L., Yang, Y., Ibanez, D.P., Lai, J., Wei, X., An, J., Guo, P., Yuan, Y., Deng, Q., Wang, Y., Liu, Y., Gao, F., Wang, J., Zaman, S., Qin, B., Wu, G., Maxwell, P.H., Xu, X., Liu, L., Li, W., and Esteban, M.A. |
2022 |
Nature |
| Mechanistic insights of CRISPR/Cas nucleases for programmable targeting
and early-stage diagnosis: A review |
Jean de Dieu Habimana, Rongqi Huang, Bertrand Muhoza, Yvan Ndayambaje Kalisa,
Xiaobo Han, Weiyue Deng, Zhiyuan Li |
2022 |
Biosensors and Bioelectronics |
| Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms |
Feixiang Bao; Lingyan Zhou; Rui Zhou; Qiaoying Huang; Junguo Chen; Sheng Zeng; Yi Wu; Liang Yang; Shufang Qian; Mengfei Wang; Xueying He1; Shan Liang; Juntao Qi; Ge Xiang; Qi Long; Jingyi Guo; Zhongfu Ying; Yanshuang Zhou; Qiuge Zhao; Jiwei Zhang; Di Zhang; Wei Sun; Mi Gao; Hao Wu; Yifan Zhao; Jinfu Nie; Min Li; Quan Chen; Jiekai Chen; Xiao Zhang; Guangjin Pan; Hong Zhang; Mingtao Li; Mei Tian; Xingguo Liu |
2022 |
Science Advances |
| Design, synthesis, and biological evaluation of novel 2’-methyl-2’-fluoro-6-
methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents |
Guoqiang Yao#; Jianchen Yu#; Cai Lin; Yujia Zhu; Anna Duana; Mengfeng Li; Jie Yuan*;Jiancun Zhang* |
2022 |
European Journal of Medicinal Chemistry |
| Structure- Based Discovery and Optimization of Furo[3,2-c]pyridin-4(5H)-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors |
Junhua Li#, Cheng Zhang#, Hongrui Xu, Chao Wang, Ruibo Dong, Hui Shen, Xiaoxi Zhuang,
Xiaoshan Chen, Qiu Li, Jibu Lu, Maofeng Zhang, Xishan Wu, Kerry M. Loomes, Yulai Zhou, Yan Zhang,
Jinsong Liu, and Yong Xu* |
2022 |
Journal of Medicinal Chemistry |
| CTCF functions as an insulator for somatic genes and a chromatin accessibility and structural regulator for pluripotency genes during reprogramming. |
Song Y#, Liang Z#, Zhang J#, Hu G#, Wang J, Li Y, Guo R, Dong X, Babarinde IA, Ping W, Sheng Y, Li H, Chen Z, Gao M, Chen Y, Zhang MQ, Hutchins AP, Fu X* and Yao H* |
2022 |
Cell Reports |
| Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors |
Qi Zhang, Bingyan Wu, Qitong Weng, Fangxiao Hu, Yunqing Lin, Chengxiang Xia, Huan Peng,Yao Wang, Xiaofei Liu, Lijuan Liu, Jiapin Xiong, Yang Geng, Yalan Zhao, Mengyun Zhang, Juan Du and Jinyong Wang |
2022 |
Cellular & Molecular Immunology |
| Human induced-T-to-natural killer cells have potent anti-tumour activities |
Zhi wu Jiang, Le Qin, Yuou Tang, Rui Liao, Jingxuan Shi, Binghe Jia, Shanglin Li, Diwei Zheng, Yuanbin Cui, Qitiing Wu, Youguo Long, Yao Yao, Zhihui Wei, Qilan Hong, Yi Wu, Yuanbang Mai, Shixue Gou, Xiaoping Li, Robert Weinkove, Sam Norton, Wei Luo, Weineng Feng, Hongsheng Zhou, Qifa Liu, Jiekai Chen, Liangxue Lai, Xinwen Chen, Duanqing Pei, Tomas Graf, Xingguo Liu, Yangqiu Li, Pentao Liu, Zhenfeng Zhang, Peng Li |
2022 |
Biomarker Research |
| Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites |
Yang Liu,Jizeng Zhou,Ting Lan1, Xiaoqing Zhou,Yang Yang, Chuan Li, Quanjun Zhang, Min Chen,
Shu Wei, Shuwen Zheng, Lingyin Cheng, Yuling Zheng, Liangxue Lai and Qingjian Zou |
2022 |
Cell Discovery |
| Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection |
Yudi Zhang, Qihong Yan, Kun Luo, Ping He, Ruitian Hou, Xinwei Zhao, Qian Wang, Haisu Yi, Huan Liang, Yijun Deng, Fengyu Hu, Feng Li, Xinglong Liu, Ying Feng, Pingchao Li, Linbing Qu, Zhaoming Chen, Qiang Pan-Hammarstr？m, Liqiang Feng,Xuefeng Niu,Ling Chen |
2022 |
Journal of Virology |
| Discovery of the first examples of threonine tyrosine kinase PROTAC degraders |
Jibu Lu, Yongjun Huang, Jing Huang, Rui He, Minhao Huang, Xiaoyun Lu, Yong Xu, Fengtao Zhou, Zhang Zhang, Ke Ding. |
2022 |
Journal of Medicinal Chemistry |
| Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection |
Yudi Zhang, Qihong Yan, Kun Luo, Ping He, Ruitian Hou, Xinwei Zhao, Qian Wang, Haisu Yi, Huan Liang, Yijun Deng, Fengyu Hu, Feng Li, Xinglong Liu, Ying Feng, Pingchao Li, Linbing Qu, Zhaoming Chen, Qiang Pan-Hammarstr？m, Liqiang Feng,Xuefeng Niu,Ling Chen |
2022 |
Journal of Virology |
| Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer |
Xiang Q, Wang C, Wu T, Zhang C, Hu Q, Luo G, Hu J, Zhuang X, Zou L, Shen H, Wu X, Zhang Y, Kong X, Liu J, Xu Y |
2022 |
Journal of Medicinal Chemistry |
