Optimized Approaches for Generation of Integration-free iPSCs from Human Urine-Derived Cells with Small Molecules and Autologous Feeder |
Di Li, Linli Wang, Jundi Hou, Qun Shen, Qianyu Chen, Xiaoshan Wang, Juan Du, Xiujuan Cai, Yongli Shan, Tian Zhang, Tiancheng Zhou, Xi Shi, Yuhua Li, Hua Zhang, Guangjin Pan |
2016 May |
Stem Cell Reports |
TGFβ signaling regulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells |
Lihui Wang, Xirui Li, Wenhao Huang, Tiancheng Zhou, Haitao Wang, Aiping Lin, Andrew Paul Hutchins1, Zhenghui Su, Qianyu Chen, Duanqing Pei, Guangjin Pan |
2016 Mar |
Scientific Reports |
ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer |
Junjian Wang, June X Zou, Xiaoqian Xue, Demin Cai, Yan Zhang, Zhijian Duan, Qiuping Xiang, Joy C Yang, Maggie C Louie, Alexander D Borowsky, Allen C Gao, Christopher P Evans, Kit S Lam1, Jianzhen Xu, Hsing-Jien Kung, Ronald M Evans, Yong Xu, Hong-Wu Chen |
2016 May |
Nature Medicine |
Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation |
Xiaoqian Xue, Yan Zhang, Zhaoxuan Liu, Ming Song, Yanli Xing, Qiuping Xiang, Zhen Wang, Zhengchao Tu, Yulai Zhou, Ke Ding, Yong Xu |
2016 Feb |
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Generation of gene-target dogs using CRISPR/Cas9 system |
Qingjian Zou,Xiaomin Wang,YunzhongLiu,Zhen Ouyang, Haibin Long, Shu Wei,Jige Xin, Bentian Zhao, Sisi Lai, Jun Shen,Qingchun Ni, Huaqiang Yang, Huilin Zhong,Li Li, Minhua Hu, Quanjun Zhang, Zhidong Zhou, Jiaxin He, Quanmei Yan, Nana Fan,Yu Zhao, Zhaoming Liu, Lin Guo, Jiao Huang,Guanguan Zhang, Jun Ying, Liangxue Lai,Xiang Gao |
2015 Dec |
Journal of Molecular Cell Biology |
Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in Human hepatoma cells |
Wenbo Ma, Caiyue Li, Shikui Yin, Jingxin Liu, Chao Gao, Zuoxian Lin, Rongqi Huang, Jufang Huang, Zhiyuan Li |
2015 Dec |
Free Radical Biology and Medicine |
Copper-Promoted Cycloaddition of α-Methylenyl Isocyanides with Benzothiazoles: Tunable Access to Benzo[d]imidazothiazoles |
Jian Wang, Jing Li,Qiang Zhu |
2015 Nov |
Organic Letters |
Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: A potential target for 'two-in-one' cancer chemoimmunotherapeutics |
Muzammal Hussain, Fei Tang, Jinsong Liu, Jiancun Zhang, Aqeel Javeed |
2015 Dec |
Cancer Letters |
Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells |
Kaimeng Huang, Xiaobai Zhang, Jiejun Shi, Mingze Yao, Jiannan Lin, Jiao Li, He Liu, Huanhuan Li, Guang Shi, Zhibin Wang, Biliang Zhang, Jiekai Chen, Guangjin Pan, Cizhong Jiang, Duanqing Pei,Hongjie Yao |
2015 Dec |
Scientific Reports |
SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains |
Yong-Heng Huang, Aleksander Jankowski, Kathryn S. E. Cheah, Shyam Prabhakar, Ralf Jauch |
2015 May |
Scientific Reports |
Organocatalytic Enantioselective Michael Reaction of Malononitrile with beta,beta-Disubstituted Nitroalkenes |
Shengwei Chen,Qinxin Lou,Yuyang Ding,Shasha Zhang,Wenhui Hu,Junling Zhao |
2015 Aug |
Advanced Synthesis & Catalysis |
Unprecedented reactions: from epichlorohydrin to epoxyglycidyl substituted divinyl ether and its conversion into epoxyglycidyl propargyl ether |
Yiwu Yao, Zheng Li, Yatao Qiu, Jinhong Bai, Jinyue Su, Dayong Zhang, Sheng Jiang |
2015 Sep |
Scientific Reports |
Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities |
Yiwu Yao, Zhengchao Tu, Chenzhong Liao, Zhen Wang, Shang Li, Hequan Yao, Zheng Li, Sheng Jiang |
2015 Oct |
Journal of Medicinal Chemistry |
An Enantioselective Synthesis of Spirobilactams through CopperCatalyzed Intramolecular Double N-Arylation and Phase Separation |
Jianguang Liu,Yingying Tian,Jialing Shi,Shasha Zhang,Qian Cai |
2015 Sep |
Angewandte Chemie-International Edition |
Copper-Catalyzed Intramolecular Desymmetric Aryl C-O Coupling for the Enantioselective Construction of Chiral Dihydrobenzofurans and Dihydrobenzopyrans |
Wenqiang Yang,Yangyuan Liu, Shasha Zhang,Qian Cai. |
2015 Jul |
Angewandte Chemie-International Edition |
The oncogene c-Jun impedes somatic cell reprogramming |
Jing Liu, Qingkai Han, Tianran Peng,Meixiu Peng, BeiWei, Dongwei Li, XiaoshanWang,Shengyong Yu, Jiaqi Yang, Shangtao Cao, Kaimeng Huang, Andrew Paul Hutchins, He Liu,Junqi Kuang, Zhiwei Zhou, Jing Chen, HaoyuWu, Lin Guo, Yongqiang Chen, You Chen, Xuejia Li,HonglingWu, Baojian Liao,Wei He, Hong Song, Hongjie Yao, Guangjin Pan, Jiekai Chen,Duanqing Pei. |
2015 Jul |
Nature Cell Biology |
Mitochondrial fusion provides an 'initial metabolic complementation' controlled by mtDNA |
Liang Yang, Qi Long, Jinglei Liu, Haite Tang, Yuxing Li, Feixiang Bao, Dajiang Qin, Duanqing Pei, Xingguo Liu. |
2015 Jul |
Cellular and Molecular Life Sciences |
Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming |
Yasong Wu,Yuan Li,Hui Zhang,Yinghua Huang,Ping Zhao,Yujia Tang,Xiaohui Qiu,Yue Ying,Wen Li,Su Ni,Meng Zhang,Longqi Liu,Yan Xu,Qiang Zhuang,Zhiwei Luo,Christina Benda,Hong Song, Baohua Liu, Liangxue Lai, Xingguo Liu, Hung-Fat Tse,Xichen Bao, Wai-Yee Chan,Miguel A. Esteban, Baoming Qin,Duanqing Pei. |
2015 Jun |
Nature Cell Biology |
Total synthesis of (+)-gelsemine via an organocatalytic Diels-Alder approach |
Xiaoming Chen, Shengguo Duan, Cheng Tao, Hongbin Zhai, Fayang G. Qiu. |
2015 May |
Nature Communications |
Copper-Catalyzed Trifluoromethylalkynylationof Isocyanides |
Jian Lei, Xiaoxing Wu,Qiang Zhu. |
2015 May |
Organic Letters |
ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells |
Yiren Xiao, Zhiwu Jiang, Yin Li, Wei Ye, Bei Jia, Minjie Zhang, Yan Xu, Donghai Wu, Liangxue Lai, Yaoyu Chen, Yingjun Chang, Xiaojun Huang, Hudan Liu, Guoliang Qing, Pentao Liu, Yangqiu Li, Bing Xu, Mei Zhong, Yao Yao, Duanqing Pei, Peng Li. |
2015 May |
Haematologica |
Valproic Acid-Induced Hepatotoxicity in Alpers Syndrome Is Associated With Mitochondrial Permeability Transition Pore Opening-Dependent Apoptotic Sensitivity in an Induced Pluripotent Stem Cell Model |
Shengbiao Li, Jingyi Guo, Zhongfu Ying, Shen Chen,Liang Yang, Keshi Chen, Qi Long, Dajiang Qin, Duanqing Pei,Xingguo Liu. |
2015 May |
Hepatology |
Copper-Catalyzed Trifluoromethylation of Trisubstituted Allylic and Homoallylic Alcohols |
Jian Lei, Xiaowu Liu, Shaolin Zhang, Shuang Jiang, Minhao Huang, Xiaoxing Wu, Qiang Zhu. |
2015 Apr |
Chemistry -A European Journal |
Small Molecule Discoidin Domain Receptor Kinase Inhibitors and Potential Medical Applications |
Yupeng Li, Xiaoyun Lu, Xiaomei Ren, Ke Ding. |
2015 Apr |
Journal of Medicinal Chemistry |
Aminopalladation-Triggered Carbene Insertion Reaction:Synthesis of 2-(1H-Indol-3-yl)acetates |
Ziwei Hu, Shuang Luo,Qiang Zhu. |
2015 Mar |
Advanced Synthesis & Catalysis |
Genomic analysis of LPS-stimulated myeloid cells identifies a common pro-inflammatory response but divergent IL-10 anti-inflammatory responses |
Andrew Paul Hutchins,Yoshiko Takahashi,Diego Miranda-Saavedra. |
2015 Mar |
Scientific Reports |
Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer |
Xiaoqing Zhou, Jige Xin, Nana Fan, Qingjian Zou, Jiao Huang, Zhen Ouyang, Yu Zhao, Bentian Zhao, Zhaoming Liu, Sisi Lai, Xiaoling Yi, Lin Guo, Miguel A. Esteban, Yangzhi Zeng, Huaqiang Yang, Liangxue Lai |
2015 Mar |
Cellular and Molecular Life Sciences |
Pd-Catalyzed Asymmetric Intramolecular Aryl C-O Bond Formation With SDP(O) Ligand: Enantioselective Synthesis of (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methanols |
Jialing Shi, Ting Wang, Yusha Huang, Xinhao Zhang, Yun-Dong Wu, Qian Cai. |
2015 Feb |
Organic Letters |
Chiral phosphoric acid-catalyzed highly enantioselective Friedel-Crafts alkylation reaction of C3-substituted indoles to β,γ-unsaturated α-ketimino esters |
Bo Bi, Qinxin Lou, Yuyang Ding, Shengwei Chen, Shasha Zhang, Wenhui Hu,Junling Zhao |
2015 Feb |
Organic Letters |
Selective killing of lung cancer cells by miRNA-506 molecule through inhibiting NF-κB p65 to evoke Reactive Oxygen Species generation and p53 activation |
Menghui Yin, Xiaoshuai Ren, Xin Zhang, Yingjun Luo, Guoxin Wang, Kailing Huang, Shipeng Feng, Xichen Bao, Ke Huang, Xiaoping He, Peizhou Liang, Zhe Wang, Hailing Tang, Jianxing He,Biliang Zhang |
2015 Feb |
Oncogene |